mRNA 翻译失调对神经紊乱的影响。
Implications of mRNA translation dysregulation for neurological disorders.
机构信息
Department of Physiology and Biophysics, School of Medicine, Case Western Reserve University, Cleveland, OH, USA.
Department of Genetics and Genome Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH, USA; Department of Neurosciences, School of Medicine Case Western Reserve University, Cleveland, OH, USA.
出版信息
Semin Cell Dev Biol. 2021 Jun;114:11-19. doi: 10.1016/j.semcdb.2020.09.005. Epub 2020 Oct 21.
Abstract
The translation of information encoded in the DNA into functional proteins is one of the tenets of cellular biology. Cell survival and function depend on the tightly controlled processes of transcription and translation. Growing evidence suggests that dysregulation in mRNA translation plays an important role in the pathogenesis of several neurodevelopmental diseases, such as autism spectrum disorder (ASD) and fragile X syndrome (FXS) as well as neurodegenerative disorders, such as Alzheimer's disease (AD), Parkinson's disease (PD) and amyotrophic lateral sclerosis (ALS). In this review, we provide an overview of mRNA translation and its modes of regulation that have been implicated in neurological disease.
摘要
将 DNA 中的信息翻译成功能性蛋白质是细胞生物学的基本原则之一。细胞的存活和功能依赖于转录和翻译的严格控制过程。越来越多的证据表明，mRNA 翻译的失调在几种神经发育疾病的发病机制中起着重要作用，如自闭症谱系障碍（ASD）和脆性 X 综合征（FXS）以及神经退行性疾病，如阿尔茨海默病（AD）、帕金森病（PD）和肌萎缩侧索硬化症（ALS）。在这篇综述中，我们概述了与神经疾病有关的 mRNA 翻译及其调节方式。
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Acta Neuropathol Commun. 2020 Jul 24;8(1):116. doi: 10.1186/s40478-020-00987-6.
2
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