Division of Pulmonary Medicine, Department of Medicine, Tokai University School of Medicine, Japan.
Department of Pathology, Tokai University School of Medicine, Japan.
Intern Med. 2021 Nov 15;60(22):3581-3584. doi: 10.2169/internalmedicine.7588-21. Epub 2021 May 22.
Hypersensitivity pneumonitis (HP) sometimes develops in people working in specific environments. We herein report a case of occupation-related HP in a citrus farmer in Japan. A 66-year-old man developed a fever, dyspnea, and general malaise in March after working near a trash dump filled with moldy tangerines. He presented with leukocytosis, bilateral lung opacities on chest radiographs, and intra-alveolar and interstitial lymphocytic inflammation with fibrotic change on a lung biopsy. His symptoms disappeared after admission and recurred on a revisit to the workplace. Fungal culture and a mycobiome analysis using next-generation sequencing suggested an association with exposure to Penicillium digitatum.
过敏性肺炎（HP）有时发生在特定环境下工作的人群中。本文报告了一例日本柑橘种植者的职业性 HP。一名 66 岁男性在 3 月于堆满发霉蜜柑的垃圾场附近工作后出现发热、呼吸困难和全身不适。胸部 X 线显示双肺浸润影，白细胞增多，肺活检显示肺泡和间质淋巴细胞炎症伴纤维化改变。入院后症状消失，但再次回到工作场所时症状复发。真菌培养和下一代测序的真菌组分析提示与接触青霉属（Penicillium digitatum）有关。
