Roushdy Tamer, Hamid Eman
Neurology Department, Faculty of Medicine, Ain Shams University, 38 Abbasia, PO 11591, Cairo, Egypt.
Egypt J Neurol Psychiatr Neurosurg. 2021;57(1):63. doi: 10.1186/s41983-021-00319-y. Epub 2021 May 19.
Severe acute respiratory syndrome corona virus 2 hit strongly and hardly the entire globe for more than 1 year with a morbidity exceeding 139 million and a mortality approaching 3 million worldwide since its emergence in China in December 2019 until April 2021. Although being termed after its ancestor the acute respiratory syndrome corona virus that emerged in 2002. Yet, the current corona virus has its unique devastating presentations being pulmonary and extra pulmonary. In the current review, a highlight on the role played by corona virus 2 on pathogenesis and outcome of stroke is presented with an attempt to point to the most approved ways through which the corona virus induce stroke being disturbance in renin angiotensin system and angiotensin-converting enzyme 2 receptors downregulation, endothelial cell damage with coagulopathy, cytokine storm, and platelet as well as outcome and risks in patients who are suffering stroke with modifiable vascular risk factors and catching the severe acute respiratory syndrome corona virus 2.
自2019年12月在中国出现至2021年4月，严重急性呼吸综合征冠状病毒2（SARS-CoV-2）在一年多的时间里对全球造成了严重冲击，全球发病率超过1.39亿，死亡率接近300万。尽管它是以2002年出现的急性呼吸综合征冠状病毒为祖先命名的。然而，目前的冠状病毒有其独特的毁灭性表现，包括肺部和肺外表现。在当前的综述中，重点介绍了冠状病毒2在中风发病机制和预后中的作用，并试图指出冠状病毒诱发中风最公认的途径，即肾素血管紧张素系统紊乱和血管紧张素转换酶2受体下调、内皮细胞损伤伴凝血病、细胞因子风暴以及血小板问题，以及患有中风且有可改变的血管危险因素并感染严重急性呼吸综合征冠状病毒2的患者的预后和风险。
