Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, 230601, China.
Institute of Respiratory Diseases, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, 230601, China.
BMC Pulm Med. 2024 Sep 17;24(1):459. doi: 10.1186/s12890-024-03269-2.
Exposure to cadmium (Cd) is associated with a reduction in lung function among patients with chronic obstructive pulmonary disease (COPD). The longitudinal relationship and mechanism underlying the link between Cd exposure and lung function changes among COPD patients are yet unknown.
The cohort study included 259 eligible patients who underwent regular professional follow-ups. Blood Cd levels and serum 8-iso-prostaglandin F2 alpha (8-iso-PGF2α) levels were assessed. Lung function was determined at baseline and follow-up research. The associations between changes in lung function and blood Cd concentration were analysed using multivariate linear and logistic regression models.
Each 1-ppb elevation in blood Cd content resulted in a 0.420 L decrease in forced vital capacity (FVC), a 0.424 L decrease in forced expiratory volume in 1 s (FEV1), a 4.341% decrease in FEV1/FVC%, and a 8.418% decrease in FEV1% predicted in patients with COPD. Blood Cd concentration showed a positive correlation with serum 8-iso-PGF2α levels in a specific range. The relative contribution of increased serum levels of 8-iso-PGF2α to Cd-induced declines in FEV1, predicted FEV1%, and FEV1/FVC% were 2.08%, 8.08%, and 13.19%, respectively.
Blood Cd levels are associated with lung function changes in COPD patients. Oxidative stress is thought to be an important mediator in Cd-induced reduction of pulmonary function.
镉（Cd）暴露与慢性阻塞性肺疾病（COPD）患者的肺功能下降有关。然而，Cd 暴露与 COPD 患者肺功能变化之间的纵向关系和潜在机制尚不清楚。
这项队列研究纳入了 259 名符合条件的患者，他们接受了定期的专业随访。评估了血液 Cd 水平和血清 8-异前列腺素 F2α（8-iso-PGF2α）水平。在基线和随访研究中测定了肺功能。使用多元线性和逻辑回归模型分析了肺功能变化与血液 Cd 浓度之间的关系。
血液 Cd 含量每升高 1ppb，COPD 患者的用力肺活量（FVC）降低 0.420L，第一秒用力呼气量（FEV1）降低 0.424L，FEV1/FVC%降低 4.341%，预计 FEV1%降低 8.418%。血液 Cd 浓度与血清 8-iso-PGF2α水平在特定范围内呈正相关。血清 8-iso-PGF2α 水平升高对 FEV1、预计 FEV1%和 FEV1/FVC%下降的相对贡献率分别为 2.08%、8.08%和 13.19%。
血液 Cd 水平与 COPD 患者的肺功能变化有关。氧化应激被认为是 Cd 诱导肺功能下降的重要介质。
