Xu Jing, Han Ming-Feng, Ma Kai-Shu, Zhang Ting, Wang Rui-Rui, Zhang Jing-Jing, Zhao Hui, Fu Lin
Department of Respiratory and Critical Care Medicine, No.2 People's Hospital of Fuyang City, Fuyang, Anhui, China.
Fuyang Infectious Disease Clinical Collage of Anhui Medical University, Fuyang, Anhui, China.
Front Pharmacol. 2025 May 20;16:1556185. doi: 10.3389/fphar.2025.1556185. eCollection 2025.
Ferritin is one of the major intracellular iron storage proteins and is implicated in the pathophysiological processes of many inflammatory diseases, but its function in community-acquired pneumonia (CAP) was unclear. The purpose of this study was to evaluate the expression of ferritin and analyze the relationship of serum ferritin with CAP.
Severe CAP patients and age- and gender-matched healthy participants were recruited for the study. Serum ferritin was detected through ELISA. Physiological characteristics were recorded.
The serum ferritin level was significantly increased in severe CAP patients upon initial hospitalization compared to healthy participants, and it decreased after therapy. Correlative analyses hinted that there were obvious relationships of serum ferritin with the indicators of blood routine, liver function, and inflammation. Moreover, linear and logistic regression analyses confirmed that the serum ferritin level was positively related to the scores of CURB-65, CRB-65, and PSI. The poor prognosis including mechanical ventilation, vasoactive agent, ICU admission, death, and longer hospital stays were assessed in severe CAP cases during hospitalization. Multivariate logistic regression showed that higher serum ferritin levels were closely linked to the poor prognostic outcomes.
There is significantly positive association between the serum ferritin level upon initial hospitalization with the severity and poor prognosis. Thus, serum ferritin could be an indicator for the determination of severity and prognosis among CAP cases.
铁蛋白是主要的细胞内铁储存蛋白之一，与多种炎症性疾病的病理生理过程有关，但其在社区获得性肺炎（CAP）中的作用尚不清楚。本研究旨在评估铁蛋白的表达，并分析血清铁蛋白与CAP的关系。
招募重症CAP患者以及年龄和性别匹配的健康参与者进行研究。通过酶联免疫吸附测定法检测血清铁蛋白。记录生理特征。
与健康参与者相比，重症CAP患者初次住院时血清铁蛋白水平显著升高，治疗后降低。相关性分析提示血清铁蛋白与血常规、肝功能及炎症指标存在明显关联。此外，线性和逻辑回归分析证实血清铁蛋白水平与CURB-65、CRB-65及PSI评分呈正相关。对重症CAP患者住院期间包括机械通气、血管活性药物使用、入住重症监护病房、死亡及住院时间延长等不良预后情况进行评估。多因素逻辑回归显示较高的血清铁蛋白水平与不良预后结果密切相关。
初次住院时的血清铁蛋白水平与病情严重程度及不良预后之间存在显著正相关。因此，血清铁蛋白可作为判断CAP患者病情严重程度及预后的指标。
