Meng Xiangxiang, Li Aixia, Yu Bin, Li Shengjun
Key Laboratory of Biofuels, Shandong Provincial Key Laboratory of Energy Genetics, Shandong Energy Institute, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, China.
The Key Laboratory of Plant Development and Environmental Adaptation Biology, Ministry of Education, School of Life Sciences, Shandong University, Qingdao 266237, China.
Comput Struct Biotechnol J. 2021 Apr 27;19:2567-2574. doi: 10.1016/j.csbj.2021.04.062. eCollection 2021.
Plants employ sophisticated mechanisms to control developmental processes and to cope with environmental changes at transcriptional and post-transcriptional levels. MicroRNAs (miRNAs) and long noncoding RNAs (lncRNAs), two classes of endogenous noncoding RNAs, are key regulators of gene expression in plants. Recent studies have identified the interplay between miRNAs and lncRNAs as a novel regulatory layer of gene expression in plants. On one hand, miRNAs target lncRNAs for the production of phased small interfering RNAs (phasiRNAs). On the other hand, lncRNAs serve as origin of miRNAs or regulate the accumulation or activity of miRNAs at transcription and post-transcriptional levels. Theses lncRNA-miRNA interplays are crucial for plant development, physiology and responses to biotic and abiotic stresses. In this review, we summarize recent advances in the biological roles, interaction mechanisms and computational predication methods of the interplay between miRNAs and lncRNAs in plants.
植物采用复杂的机制在转录和转录后水平上控制发育过程并应对环境变化。微小RNA（miRNA）和长链非编码RNA（lncRNA）这两类内源性非编码RNA是植物基因表达的关键调节因子。最近的研究已确定miRNA和lncRNA之间的相互作用是植物基因表达的一种新型调节层面。一方面，miRNA靶向lncRNA以产生阶段性小干扰RNA（phasiRNA）。另一方面，lncRNA作为miRNA的来源，或在转录和转录后水平上调节miRNA的积累或活性。这些lncRNA-miRNA相互作用对植物发育、生理以及对生物和非生物胁迫的反应至关重要。在本综述中，我们总结了植物中miRNA和lncRNA相互作用在生物学作用、相互作用机制和计算预测方法方面的最新进展。
