• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

一项关于肌肉注射氯胺酮治疗严重且持久的饮食失调症合并难治性抑郁症患者的纵向病例系列研究。

A longitudinal case series of IM ketamine for patients with severe and enduring eating disorders and comorbid treatment-resistant depression.

作者信息

Schwartz Terry, Trunko Mary Ellen, Feifel David, Lopez Emily, Peterson Danika, Frank Guido K W, Kaye Walter

机构信息

Department of Psychiatry University of California San Diego San Diego CA USA.

出版信息

Clin Case Rep. 2021 Apr 4;9(5):e03869. doi: 10.1002/ccr3.3869. eCollection 2021 May.

DOI:10.1002/ccr3.3869
PMID:34026123
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8117825/
Abstract

Severe and enduring eating disorders (EDs) have the highest mortality rate of all psychiatric illnesses (Arch Gen Psychiatry, 2011, , 724), especially when comorbid with treatment-resistant depression (TRD) (Psychiatr Res, 2016, , 45). We report on four patients with enduring EDs and TRD treated with repeat ketamine over 12 + months, showing improvement in depression with only modest changes in ED symptoms.

摘要

严重且持久的饮食失调症（EDs）在所有精神疾病中死亡率最高（《美国精神病学杂志》，2011年，第724页），尤其是与难治性抑郁症（TRD）共病时（《精神病学研究》，2016年，第45页）。我们报告了4例患有持久EDs和TRD的患者，他们在12个多月的时间里接受了重复氯胺酮治疗，结果显示抑郁症症状有所改善，而ED症状仅有适度变化。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e54/8117825/09c83af630a3/CCR3-9-e03869-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e54/8117825/09c83af630a3/CCR3-9-e03869-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e54/8117825/09c83af630a3/CCR3-9-e03869-g001.jpg

相似文献

1
A longitudinal case series of IM ketamine for patients with severe and enduring eating disorders and comorbid treatment-resistant depression.一项关于肌肉注射氯胺酮治疗严重且持久的饮食失调症合并难治性抑郁症患者的纵向病例系列研究。
Clin Case Rep. 2021 Apr 4;9(5):e03869. doi: 10.1002/ccr3.3869. eCollection 2021 May.
2
Efficacy, Safety, and Durability of Repeated Ketamine Infusions for Comorbid Posttraumatic Stress Disorder and Treatment-Resistant Depression.重复氯胺酮输注治疗共病创伤后应激障碍和治疗抵抗性抑郁症的疗效、安全性和持久性。
J Clin Psychiatry. 2018 May/Jun;79(3). doi: 10.4088/JCP.17m11634.
3
The Association of Malnutrition, illness duration, and pre-morbid weight status with anxiety and depression symptoms in adolescents and young adults with restrictive eating disorders: a cross-sectional study.青少年和年轻成人限制性饮食障碍患者中营养不良、病程及病前体重状况与焦虑和抑郁症状的相关性：一项横断面研究
J Eat Disord. 2021 May 17;9(1):60. doi: 10.1186/s40337-021-00415-7.
4
The prevalence of eating disorders (EDs) and comorbid psychiatric disorders in adolescents: a two-stage community-based study.青少年饮食失调（EDs）及共病精神障碍的患病率：一项基于社区的两阶段研究。
Turk Psikiyatri Derg. 2011 Winter;22(4):205-12.
5
A case series of group-based ketamine-assisted psychotherapy for patients in residential treatment for eating disorders with comorbid depression and anxiety disorders.一组针对患有饮食失调合并抑郁症和焦虑症的住院患者进行基于氯胺酮辅助心理治疗的病例系列。
J Eat Disord. 2022 May 6;10(1):65. doi: 10.1186/s40337-022-00588-9.
6
Repeated intravenous infusions of ketamine: Neurocognition in patients with anxious and nonanxious treatment-resistant depression.重复静脉输注氯胺酮：焦虑和非焦虑性治疗抵抗性抑郁症患者的神经认知。
J Affect Disord. 2019 Dec 1;259:1-6. doi: 10.1016/j.jad.2019.08.012. Epub 2019 Aug 12.
7
Augmentation Therapy With Serial Intravenous Ketamine Over 18 Months in a Patient With Treatment Resistant Depression.一名难治性抑郁症患者接受为期18个月的连续静脉注射氯胺酮强化治疗。
Clin Neuropharmacol. 2015 Sep-Oct;38(5):212-6. doi: 10.1097/WNF.0000000000000104.
8
Use of Ketamine in Elderly Patients with Treatment-Resistant Depression.使用氯胺酮治疗治疗抵抗性老年抑郁症患者。
Curr Psychiatry Rep. 2017 Nov 15;19(12):107. doi: 10.1007/s11920-017-0855-x.
9
10
Low-dose ketamine for treatment resistant depression in an academic clinical practice setting.低剂量氯胺酮用于学术临床实践环境中难治性抑郁症的治疗
J Affect Disord. 2017 Oct 15;221:283-288. doi: 10.1016/j.jad.2017.06.043. Epub 2017 Jun 20.

引用本文的文献

1
Psilocybin in the treatment of eating disorders: a systematic review of the literature and registered clinical trials.裸盖菇素治疗饮食失调：文献及注册临床试验的系统评价
Eat Weight Disord. 2025 Jul 29;30(1):58. doi: 10.1007/s40519-025-01771-y.
2
Prescription and Nonprescription Drug Use Among People With Eating Disorders.饮食失调人群的处方药和非处方药使用情况
JAMA Netw Open. 2025 Jul 1;8(7):e2522406. doi: 10.1001/jamanetworkopen.2025.22406.
3
Ketamine-assisted therapy within a community of practice: a novel approach to disordered eating.

本文引用的文献

1
Low-dose ketamine for treatment resistant depression in an academic clinical practice setting.低剂量氯胺酮用于学术临床实践环境中难治性抑郁症的治疗
J Affect Disord. 2017 Oct 15;221:283-288. doi: 10.1016/j.jad.2017.06.043. Epub 2017 Jun 20.
2
Efficacy of ketamine in the rapid treatment of major depressive disorder: a meta-analysis of randomized, double-blind, placebo-controlled studies.氯胺酮在快速治疗重度抑郁症中的疗效：一项随机、双盲、安慰剂对照研究的荟萃分析。
Neuropsychiatr Dis Treat. 2016 Nov 3;12:2859-2867. doi: 10.2147/NDT.S117146. eCollection 2016.
3
Predictors of outcomes in outpatients with anorexia nervosa - Results from the ANTOP study.
实践社区中的氯胺酮辅助治疗：一种治疗饮食失调的新方法。
Ther Adv Psychopharmacol. 2025 Jul 14;15:20451253251356980. doi: 10.1177/20451253251356980. eCollection 2025.
4
Novel potential pharmacological approaches in treating eating disorders comorbid with substance use disorders.治疗与物质使用障碍共病的饮食失调的新型潜在药理学方法。
Biomed Pharmacother. 2025 Aug;189:118327. doi: 10.1016/j.biopha.2025.118327. Epub 2025 Jul 4.
5
Reconnecting through dissociation: a 5-month follow-up case study on ketamine-assisted psychotherapy for anorexia nervosa.通过解离重新建立联系：一项关于氯胺酮辅助心理治疗神经性厌食症的5个月随访案例研究。
J Eat Disord. 2025 Jun 10;13(1):107. doi: 10.1186/s40337-025-01313-y.
6
Biological treatments for co-occurring eating disorders and psychological trauma: a systematic review.共病饮食失调与心理创伤的生物治疗：一项系统综述。
Front Psychiatry. 2025 Feb 21;16:1523269. doi: 10.3389/fpsyt.2025.1523269. eCollection 2025.
7
Ketamine as adjuvant treatment in eating disorders: an exploratory study of a case series and retrospective analysis.氯胺酮作为饮食失调的辅助治疗：一项病例系列探索性研究及回顾性分析。
J Eat Disord. 2025 Mar 17;13(1):48. doi: 10.1186/s40337-025-01232-y.
8
[Pharmacotherapy of eating disorders-An update].[饮食失调的药物治疗——最新进展]
Nervenarzt. 2025 May;96(3):230-237. doi: 10.1007/s00115-025-01804-y. Epub 2025 Feb 20.
9
Pharmacotherapeutic strategies for the treatment of anorexia nervosa - novel targets to break a vicious cycle.治疗神经性厌食症的药物治疗策略——打破恶性循环的新靶点。
Expert Opin Pharmacother. 2024 Dec;25(17):2253-2265. doi: 10.1080/14656566.2024.2424316. Epub 2024 Nov 5.
10
Improvement in depressive symptoms in a patient with severe and enduring anorexia nervosa and comorbid major depressive disorder using psychotherapy-assisted IV ketamine : a case report.使用心理治疗辅助静脉注射氯胺酮改善重度及持续性神经性厌食症合并重度抑郁症患者的抑郁症状：一例报告
J Eat Disord. 2024 Jun 12;12(1):79. doi: 10.1186/s40337-024-01039-3.
神经性厌食症门诊患者结局的预测因素——来自 ANTOP 研究的结果。
Psychiatry Res. 2016 Oct 30;244:45-50. doi: 10.1016/j.psychres.2016.07.002. Epub 2016 Jul 8.
4
Placebo-controlled pilot trial testing dose titration and intravenous, intramuscular and subcutaneous routes for ketamine in depression.安慰剂对照的试点试验，测试氯胺酮治疗抑郁症的剂量滴定以及静脉、肌肉和皮下给药途径。
Acta Psychiatr Scand. 2016 Jul;134(1):48-56. doi: 10.1111/acps.12572. Epub 2016 Mar 30.
5
Meta-analysis of short- and mid-term efficacy of ketamine in unipolar and bipolar depression.氯胺酮治疗单相和双相抑郁的短期和中期疗效的荟萃分析。
Psychiatry Res. 2015 Dec 15;230(2):682-8. doi: 10.1016/j.psychres.2015.10.032. Epub 2015 Oct 30.
6
Treatment of patients with severe and enduring eating disorders.严重和持久的进食障碍患者的治疗。
Curr Opin Psychiatry. 2015 Nov;28(6):473-7. doi: 10.1097/YCO.0000000000000191.
7
Acute antidepressant effects of intramuscular versus intravenous ketamine.肌肉注射与静脉注射氯胺酮的急性抗抑郁作用
Indian J Psychol Med. 2014 Jan;36(1):71-6. doi: 10.4103/0253-7176.127258.
8
A 12-month naturalistic observation of three patients receiving repeat intravenous ketamine infusions for their treatment-resistant depression.对 3 名接受重复静脉注射氯胺酮治疗难治性抑郁症的患者进行了为期 12 个月的自然观察。
J Affect Disord. 2013 May;147(1-3):416-20. doi: 10.1016/j.jad.2012.10.015. Epub 2012 Nov 22.
9
Mortality rates in patients with anorexia nervosa and other eating disorders. A meta-analysis of 36 studies.神经性厌食症及其他饮食失调患者的死亡率。36项研究的荟萃分析。
Arch Gen Psychiatry. 2011 Jul;68(7):724-31. doi: 10.1001/archgenpsychiatry.2011.74.
10
Eating Disorder Examination Questionnaire (EDE-Q): norms for young adult women.饮食失调检查问卷（EDE-Q）：年轻成年女性的常模
Behav Res Ther. 2006 Jan;44(1):53-62. doi: 10.1016/j.brat.2004.12.003.