Ali Noor-E-Seher, Alyono Jennifer C, Song Yohan, Kouhi Ali, Blevins Nikolas H
Department of Otolaryngology, Stanford University, Stanford, California, United States.
J Neurol Surg B Skull Base. 2021 Jun;82(3):378-382. doi: 10.1055/s-0039-3400223. Epub 2019 Nov 14.
This study aimed to determine the incidence of postoperative venous thromboembolism (VTE) in adults undergoing neurotologic surgery at a single center. The records of adults undergoing neurotologic surgery from August 2009 to December 2016 at a tertiary care hospital were reviewed for VTE within 30 postoperative days. Particular attention was focused on postoperative diagnosis codes, imaging, and a keyword search of postoperative notes. Caprini risk scores were calculated. Among 387 patients, 5 experienced postoperative VTE including 3 cases of pulmonary embolism (PE) and 2 cases of isolated deep vein thrombosis (DVT). All patients were given sequential compression devices perioperatively, and none received preoperative chemoprophylaxis. Patients with Caprini score > 8 had a significantly higher rate of VTE compared with those < 8 (12.5 vs. 1%, = 0.004). Receiver operating characteristic analysis revealed the Caprini risk assessment model to be a fair predictor of VTE, with a C-statistic of 0.70 (95% confidence interval [CI]: 0.49-0.92). While no specific validated VTE risk stratification scheme has been widely accepted for patients undergoing neurotologic surgery, the Caprini score appears to be a useful predictor of risk. The benefits of chemoprophylaxis should be balanced with the risks of intraoperative bleeding, as well as the potential for postoperative intracranial hemorrhage.
本研究旨在确定在单一中心接受神经耳科手术的成人患者术后静脉血栓栓塞(VTE)的发生率。
回顾了一家三级护理医院2009年8月至2016年12月期间接受神经耳科手术的成人患者术后30天内发生VTE的记录。特别关注术后诊断编码、影像学检查以及术后记录的关键词搜索。计算了Caprini风险评分。
在387例患者中,5例发生术后VTE,包括3例肺栓塞(PE)和2例孤立性深静脉血栓形成(DVT)。所有患者围手术期均使用了序贯加压装置,且均未接受术前化学预防。Caprini评分>8的患者VTE发生率显著高于评分<8的患者(12.5%对1%,P = 0.004)。受试者工作特征分析显示,Caprini风险评估模型对VTE的预测效果尚可,C统计量为0.70(95%置信区间[CI]:0.49 - 0.92)。
虽然目前尚无针对接受神经耳科手术患者的经过验证的特定VTE风险分层方案被广泛接受,但Caprini评分似乎是一个有用的风险预测指标。化学预防的益处应与术中出血风险以及术后颅内出血的可能性相权衡。