Department of Nuclear Medicine, Molecular Imaging & Therapeutic Medicine Research Center, Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonbuk National University Medical School and Hospital, Jeonju, Korea.
Department of Radiation Oncology, Research Institute of Clinical Medicine of Jeonbuk National University-Biomedical Research Institute of Jeonbuk National University Hospital, Jeonbuk National University Medical School and Hospital, Jeonju, Korea.
Yonsei Med J. 2021 Jun;62(6):555-562. doi: 10.3349/ymj.2021.62.6.555.
This study aimed to investigate the effect of ursodeoxycholic acid (UDCA) on the biodistribution and excretion of technetium-99m (Tc-99m)-labeled radiopharmaceuticals.
Tc-99m hydroxy-methylene-diphosphonate (HDP), Tc-99m pertechnetate, and Tc-99m dimercaptosuccinic acid (DMSA) were injected via the tail vein of rats. After 30 min, the control group was administered saline, and the UDCA group was given UDCA orally. Scintigraphy images were acquired after 30 min and 1, 2, 3, and 4 h. Radioactivity and rate of change were compared. Tc-99m mercaptoacetyltriglycine (MAG₃) imaging was also performed.
In image analysis of Tc-99m HDP, radioactivity of the buttock was lower in the UDCA group at 4 h. Rates of change in the buttock were significantly different at 3 h-30 min and 4 h-30 min, and buttock radioactivity in the UDCA group had decreased more. In analysis of Tc-99m pertechnetate, radioactivity of the buttock was higher in the control group. Rates of change in the thyroid gland and buttock were different at 1 h-30 min, 3 h-30 min, and 4 h-30 min, with radioactivity in the UDCA group decreasing more. In the analysis of Tc-99m DMSA, while the radioactivity of the kidneys in the control group showed little decrease at 1 h-30 min, that in the UDCA group increased. In the analysis of Tc-99m MAG₃ images, radioactivity and radioactivity/total body radioactivity (TBA) values for the kidneys were higher in the UDCA group at 2 min. At 5 and 10 min, radioactivity/TBA values for soft tissue in the UDCA group were lower than those in the control group.
This study demonstrated that administration of UDCA increases renal excretion and soft tissue clearance of radiopharmaceuticals. This investigation could contribute to the broadening of applications of UDCA.
本研究旨在探讨熊去氧胆酸（UDCA）对锝-99m（Tc-99m）标记放射性药物的生物分布和排泄的影响。
Tc-99m 羟基亚甲基二膦酸盐（HDP）、Tc-99m 高锝酸盐和 Tc-99m 二巯丁二酸（DMSA）经尾静脉注入大鼠体内。30 分钟后，对照组给予生理盐水，UDCA 组给予 UDCA 口服。30 分钟和 1、2、3、4 小时后采集闪烁显像图像。比较放射性和变化率。还进行了 Tc-99m 巯基乙酰三甘氨酸（MAG₃）成像。
在 Tc-99m HDP 的图像分析中，4 小时时 UDCA 组臀部的放射性较低。3 小时-30 分钟和 4 小时-30 分钟时，臀部的变化率差异显著，UDCA 组的臀部放射性下降更多。在 Tc-99m 高锝酸盐分析中，对照组臀部的放射性较高。甲状腺和臀部的变化率在 1 小时-30 分钟、3 小时-30 分钟和 4 小时-30 分钟时不同，UDCA 组的放射性下降更多。在 Tc-99m DMSA 分析中，对照组的肾脏放射性在 1 小时-30 分钟时几乎没有减少，而 UDCA 组的肾脏放射性增加。在 Tc-99m MAG₃ 图像分析中，2 分钟时 UDCA 组肾脏的放射性和放射性/全身放射性（TBA）值较高。在 5 分钟和 10 分钟时，UDCA 组软组织的放射性/TBA 值低于对照组。
本研究表明，UDCA 给药可增加放射性药物的肾脏排泄和软组织清除率。本研究有助于拓宽 UDCA 的应用。
