Theaker J M, Gatter K C, Brown D C, Heryet A, Davies M J
University of Oxford, Nuffield Department of Pathology, John Radcliffe Hospital, England.
Hum Pathol. 1988 Aug;19(8):974-9. doi: 10.1016/s0046-8177(88)80015-7.
In an immunohistochemical study of six cases of giant cell myocarditis, the typical giant cells have been shown to express up to four different macrophage-associated antigens, but not desmin, the intermediate filament protein characteristic of muscle cells. These results support the view that the giant cells have a macrophage rather than a myogenic origin. In contrast, the giant cells found in regenerating skeletal muscle have the immunophenotype of muscle cells and not of macrophages supporting their muscle origin.
在一项对6例巨细胞性心肌炎的免疫组织化学研究中，典型的巨细胞已被证明可表达多达四种不同的巨噬细胞相关抗原，但不表达结蛋白，结蛋白是肌肉细胞特有的中间丝蛋白。这些结果支持了巨细胞起源于巨噬细胞而非肌源性的观点。相比之下，在再生骨骼肌中发现的巨细胞具有肌肉细胞而非巨噬细胞的免疫表型，这支持了它们的肌肉起源。
