Division of Cardiovascular Medicine, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri; Center for Cardiovascular Research, Cardiovascular Division, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri; Department of Developmental Biology, Washington University School of Medicine, St. Louis, Missouri; Department of Immunology and Pathology, Washington University School of Medicine, St. Louis, Missouri.
Baker Heart and Diabetes Research Institute, Melbourne, Australia; Centre for Cardiovascular Biology and Disease Research, La Trobe University, Melbourne, Australia.
J Am Coll Cardiol. 2018 Oct 30;72(18):2213-2230. doi: 10.1016/j.jacc.2018.08.2149.
Macrophages are integral components of cardiac tissue and exert profound effects on the healthy and diseased heart. Paradigm shifting studies using advanced molecular techniques have revealed significant complexity within these macrophage populations that reside in the heart. In this final of a 4-part review series covering the macrophage in cardiovascular disease, the authors review the origins, dynamics, cell surface markers, and respective functions of each cardiac macrophage subset identified to date, including in the specific scenarios of myocarditis and after myocardial infarction. Looking ahead, a deeper understanding of the diverse and often dichotomous functions of cardiac macrophages will be essential for the development of targeted therapies to mitigate injury and orchestrate recovery of the diseased heart. Moreover, as macrophages are critical for cardiac healing, they are an emerging focus for therapeutic strategies aimed at minimizing cardiomyocyte death, ameliorating pathological cardiac remodeling, and for treating heart failure and after myocardial infarction.
巨噬细胞是心脏组织的重要组成部分，对健康和患病的心脏都有深远的影响。使用先进分子技术的范式转变研究揭示了这些存在于心脏中的巨噬细胞群体具有显著的复杂性。在涵盖心血管疾病中巨噬细胞的 4 部分综述系列的最后一部分中，作者综述了迄今为止鉴定的每种心脏巨噬细胞亚群的起源、动态、细胞表面标志物和各自的功能，包括在心肌炎和心肌梗死后的特定情况下。展望未来，深入了解心脏巨噬细胞的多样化和经常是二分法的功能对于开发靶向治疗以减轻损伤和协调患病心脏的恢复至关重要。此外，由于巨噬细胞对心脏愈合至关重要，因此它们是治疗策略的新兴重点，旨在最大限度地减少心肌细胞死亡、改善病理性心脏重塑以及治疗心力衰竭和心肌梗死后。
