Ghidini O, Azzurro M, Vita G, Sartori G
Reparto Medicina Interna, Ospedale Bussolengo, Verona, Italy.
Int J Clin Pharmacol Ther Toxicol. 1988 Apr;26(4):217-20.
To evaluate the therapeutic efficacy of L-carnitine in elderly subjects suffering from heart failure, secondary to ischemic and/or hypertensive heart disease, 38 patients (22 men, 16 women) were studied, aged from 65 to 82 years. In addition to traditional therapy (digitalis, diuretics, antiarrhythmic agents) given in all cases, 21 patients received oral L-carnitine on the basis of a randomized protocol in 1-g doses twice daily for 45 days (the other 17 received placebo). In the group treated with L-carnitine, a distinct improvement was observed in both subjective and objective conditions; reduced heart rate, edema and dyspnea, increased diuresis and a marked reduction in daily digitalis consumption. L-carnitine treatment also induced a significant reduction in serum cholesterol and triglyceride levels. No adverse reactions attributable to L-carnitine administration were observed in any of the patients.
为评估左旋肉碱对继发于缺血性和/或高血压性心脏病的老年心力衰竭患者的治疗效果，我们对38例患者（22例男性，16例女性）进行了研究，年龄在65至82岁之间。所有患者均接受传统治疗（洋地黄、利尿剂、抗心律失常药物），此外，21例患者根据随机方案接受口服左旋肉碱，剂量为每日两次，每次1克，共45天（另外17例接受安慰剂）。在接受左旋肉碱治疗的组中，主观和客观状况均有明显改善；心率降低、水肿和呼吸困难减轻、尿量增加，每日洋地黄用量显著减少。左旋肉碱治疗还使血清胆固醇和甘油三酯水平显著降低。所有患者均未观察到与左旋肉碱给药相关的不良反应。
