Acerbi D, Bonati C, Boscarino G, Bufalino L, Cesari F, D'Ambrosio E, Mansanti P, Scali G
Pharmacotoxicological Research Laboratories, Chiesi Farmaceutici S.p.A., Parma, Italy.
Int J Clin Pharmacol Res. 1988;8(3):175-80.
The age effect on the kinetics of piroxicam at the steady-state after oral administration of piroxicam beta-cyclodextrin was evaluated. The mean plasma concentration of piroxicam at the steady-state was significantly higher in elderly subjects (9.30 +/- 0.69 micrograms/ml mean +/- s.e.) than in younger adults (6.24 +/- 0.58 micrograms/ml mean +/- s.e.). Even though the distribution volume tended to be lower in elderly subjects (106.37 ml/kg), it did not show substantial differences in the two groups whereas the correlation between clearance and age was significant (p less than 0.05). It is therefore confirmed that piroxicam beta-cyclodextrin has the same pharmacokinetic behaviour at the steady-state in elderly subjects, as the active principle in a non-complexed form.
评估了年龄对口服吡罗昔康β-环糊精后稳态下吡罗昔康动力学的影响。老年受试者（平均9.30±0.69微克/毫升，平均值±标准误）稳态下吡罗昔康的平均血浆浓度显著高于年轻成年人（6.24±0.58微克/毫升，平均值±标准误）。尽管老年受试者的分布容积趋于较低（106.37毫升/千克），但两组之间未显示出实质性差异，而清除率与年龄之间的相关性显著（p<0.05）。因此证实，吡罗昔康β-环糊精在老年受试者稳态下具有与非复合形式活性成分相同的药代动力学行为。
