Department of Oral Immunology and Infectious Diseases, University of Louisville School of Dentistry, Louisville, Kentucky, USA.
Faculty of Biochemistry, Biophysics and Biotechnology, Department of Microbiology, Jagiellonian University, Kraków, Poland.
Mol Oral Microbiol. 2021 Aug;36(4):225-232. doi: 10.1111/omi.12345. Epub 2021 Jun 8.
RagA and RagB proteins are major components of the outer membrane of the oral pathogen Porphyromonas gingivalis and, while recently suggested to represent a novel peptide uptake system, their full function is still under investigation. Herein, we (a) discuss the evidence that the rag locus contributes to P. gingivalis virulence; (b) provide insight to Rag protein potential biological function in macromolecular transport and other aspects of bacterial physiology; (c) address the host response to Rag proteins which are immunodominant and immunomodulatory; and (d) review the potential of Rag-focused therapeutic strategies for the control of periodontal diseases.
RagA 和 RagB 蛋白是口腔病原体牙龈卟啉单胞菌外膜的主要成分，尽管最近被认为代表了一种新型的肽摄取系统，但它们的全部功能仍在研究中。在此，我们（a）讨论 rag 基因座有助于牙龈卟啉单胞菌毒力的证据；（b）提供 Rag 蛋白在大分子运输和细菌生理学其他方面的潜在生物学功能的见解；（c）探讨宿主对免疫显性和免疫调节的 Rag 蛋白的反应；（d）综述了针对控制牙周病的 Rag 蛋白靶向治疗策略的潜力。
