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一种用于视网膜母细胞瘤的外照射治疗技术。

An external beam treatment technique for retinoblastoma.

作者信息

Chin L M, Harter W, Svensson G K, Cassady J R

机构信息

Joint Center for Radiation Therapy, Harvard Medical School, Boston, MA 02115.

出版信息

Int J Radiat Oncol Biol Phys. 1988 Aug;15(2):455-60. doi: 10.1016/s0360-3016(98)90030-x.

Abstract

The main difficulty in the irradiation of retinoblastoma has been to deliver a high uniform dose to the entire retinal surface and spare the lens. Conventional techniques are inadequate to deliver an acceptable dose distribution especially for cases when there are both anterior and posterior lesions. We have developed a procedure to deliver a high dose anteriorly at the ora serrata for a compromise of about 30-35% of the target dose to the lens. The technique consists of 3 pairs of non-coplanar arcs using a 4 MV accelerator. This technique may offer a higher probability of tumor control and cure when gross tumor is present at the ora serrata when compared to the conventional techniques using lateral techniques.

摘要

视网膜母细胞瘤放疗的主要困难在于向整个视网膜表面提供高均匀剂量并保护晶状体。传统技术不足以提供可接受的剂量分布,特别是对于同时存在前部和后部病变的情况。我们已经开发出一种程序,在前部锯齿缘处给予高剂量,使晶状体接受的剂量约为靶剂量的30%至35%。该技术使用4兆伏加速器,由3对非共面弧形照射组成。与使用侧方照射技术的传统方法相比,当锯齿缘处存在肉眼可见的肿瘤时,该技术可能提供更高的肿瘤控制和治愈概率。

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