卡他诺辛A和B的分离与表征

Isolation and characterization of katanosins A and B.

作者信息

Shoji J, Hinoo H, Matsumoto K, Hattori T, Yoshida T, Matsuura S, Kondo E

机构信息

Shionogi Research Laboratories, Shionogi & Co., Ltd., Osaka, Japan.

出版信息

J Antibiot (Tokyo). 1988 Jun;41(6):713-8. doi: 10.7164/antibiotics.41.713.

DOI:10.7164/antibiotics.41.713

PMID:3403364

Abstract

Two peptide antibiotics katanosins A and B were isolated from the culture broth of a strain related to the genus Cytophaga. These antibiotics are basic peptides soluble in aqueous alcohols. The molecular formulae C57H95N15O17 for A and C58H97N15O17 for B were indicated. The constituent amino acids of katanosin A are suggested to be Thr (1), Ser (1), Val (1), Leu (3), Arg (1) and three unusual amino acids. In katanosin B, the Val residue is replaced by Ile. Katanosins A and B are active against Gram-positive bacteria in vitro and in vivo.

摘要

从一种与噬纤维菌属相关的菌株的培养液中分离出了两种肽类抗生素——卡塔诺辛A和B。这些抗生素是可溶于醇水溶液的碱性肽。已确定A的分子式为C57H95N15O17，B的分子式为C58H97N15O17。卡塔诺辛A的组成氨基酸推测为苏氨酸（1个）、丝氨酸（1个）、缬氨酸（1个）、亮氨酸（3个）、精氨酸（1个）以及三种不常见的氨基酸。在卡塔诺辛B中，缬氨酸残基被异亮氨酸取代。卡塔诺辛A和B在体外和体内对革兰氏阳性菌均有活性。