硫霉素的分离与特性鉴定

Isolation and characterization of thioxamycin.

作者信息

Matsumoto M, Kawamura Y, Yasuda Y, Tanimoto T, Matsumoto K, Yoshida T, Shoji J

机构信息

Shionogi Research Laboratories, Shionogi & Co., Ltd., Osaka, Japan.

出版信息

J Antibiot (Tokyo). 1989 Oct;42(10):1465-9. doi: 10.7164/antibiotics.42.1465.

DOI:10.7164/antibiotics.42.1465

PMID:2808134

Abstract

A new peptide antibiotic named thioxamycin which contained thiazole and oxazole rings was isolated from the culture broth of Streptomyces sp. The antibiotic is acidic and lipophilic in nature. A molecular formula, C52H48N16O15S4, was indicated by elemental analysis and MS. One mol of threonine and three unusual amino acids were detected by amino acid analysis of the acid hydrolysate. The antibiotic is active in vitro against anaerobic Gram-positive and Gram-negative bacteria and also aerobic Gram-positive bacteria.

摘要

从链霉菌属的培养液中分离出一种名为硫霉素的新型肽类抗生素，它含有噻唑环和恶唑环。该抗生素呈酸性，具有亲脂性。元素分析和质谱分析表明其分子式为C52H48N16O15S4。对酸水解产物进行氨基酸分析，检测到1摩尔苏氨酸和3种不寻常的氨基酸。该抗生素在体外对厌氧革兰氏阳性菌和革兰氏阴性菌以及好氧革兰氏阳性菌均有活性。