由噬细胞菌属产生的新型大环内酯类抗生素YM-32890 A和B
YM-32890 A and B, new types of macrolide antibiotics produced by Cytophaga sp.
作者信息
Kamigiri K, Tokunaga T, Sugawara T, Nagai K, Shibazaki M, Setiawan B, Rantiatmodjo R M, Morioka M, Suzuki K
机构信息
Microbiology Research Dept. Drug Serendipity Research Labs., Yamanouchi Pharmaceutical Co., Ltd., Tokyo, Japan.
出版信息
J Antibiot (Tokyo). 1997 Jul;50(7):556-61. doi: 10.7164/antibiotics.50.556.
Two new types of macrolide antibiotics, YM-32890 A and B, have been isolated from the fermentation broth of cytophaga sp. YL-02905S. In this paper, the taxonomy of the producing strain, fermentation, isolation, structure elucidation, and biological activity of the antibiotics are reported. YM-32890 A inhibits the growth of staphylococci including a macrolide-resistant strain, but shows no antimicrobial activity against other Gram-positive, Gram-negative bacteria and yeast.
从纤维粘菌属菌株YL - 02905S的发酵液中分离出了两种新型大环内酯类抗生素，即YM - 32890 A和B。本文报道了产生菌的分类学、发酵、分离、结构解析以及这些抗生素的生物活性。YM - 32890 A能抑制包括耐大环内酯菌株在内的葡萄球菌的生长，但对其他革兰氏阳性菌、革兰氏阴性菌和酵母菌没有抗菌活性。
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