亚甲基乳杆菌素，一种来自青霉菌属的新型抗肿瘤抗生素。

Methylenolactocin, a novel antitumor antibiotic from Penicillium sp.

作者信息

Park B K, Nakagawa M, Hirota A, Nakayama M

机构信息

Department of Food Science and Technology, College of Agriculture, Kang Woen National University, Chun Cheon, Korea.

出版信息

J Antibiot (Tokyo). 1988 Jun;41(6):751-8. doi: 10.7164/antibiotics.41.751.

DOI:10.7164/antibiotics.41.751

PMID:3403369

Abstract

A novel antitumor antibiotic, methylenolactocin, was isolated from the culture filtrate of a new isolate of fungus identified as Penicillium sp. The fermentation yield reached about 100 mg per liter of the broth. Methylenolactocin has the molecular formula of C11H16O4 and possess an exomethylene lactone structure. Its structure was determined to be 3-carboxy-2-methylene-4-nonanolide by spectroscopic data. It is active against some Gram-positive bacteria and it prolongs the life span of mice inoculated with Ehrlich carcinoma.

摘要

一种新型抗肿瘤抗生素——亚甲基乳杆菌素，是从一种被鉴定为青霉菌属的新分离真菌的培养滤液中分离出来的。发酵产量达到每升肉汤约100毫克。亚甲基乳杆菌素的分子式为C11H16O4，具有外亚甲基内酯结构。通过光谱数据确定其结构为3-羧基-2-亚甲基-4-壬醇内酯。它对一些革兰氏阳性细菌有活性，并且能延长接种艾氏癌的小鼠的寿命。