Department of Internal Medicine, Kangbuk Samsung Hospital, Sungkyunkwan University School of Medicine, 29 Saemunan-ro, Jongno-Gu, Seoul, 03181, Republic of Korea.
Jung Jaemyun Internal Medicine Clinic, Seoul, Republic of Korea.
Sci Rep. 2021 May 25;11(1):10928. doi: 10.1038/s41598-021-90339-8.
Hyperadiponectemia is paradoxically associated with renal disease progression and mortality in chronic kidney disease (CKD). Its association with health-related quality of life (HR-QOL) is unknown. This study aimed to verify the association between adiponectin and HR-QOL in Korean pre-dialysis CKD cohort. This cross-sectional study analyzed 1551 pre-dialysis CKD patients from KNOW-CKD (KoreaN Cohort Study for Outcome in Patients With Chronic Kidney Disease). Participants were categorized into three tertiles (T1-T3) according to adiponectin levels. HR-QOL was assessed using SF-36. High physical component summary (PCS) and mental component summary (MCS) were defined as highest quartile of each score. Multivariate logistic regression was used to analyze odds ratio (OR) and 95% confidence interval (CI) for high PCS and MCS. Prevalence of high PCS were 33.3%, 27.5%, and 17.0% and that of high MCS were 31.7%, 24.8%, and 21.3% for T1, T2, and T3 (both p for trend < 0.001). The adjusted OR [95% CI] of T1 and T2 in reference to T3 were 1.56 [1.09-2.23] and 1.19 [0.85-1.68] for high PCS and 1.19 [0.85-1.68] and 0.94 [0.68-1.29] for high MCS. Serum adiponectin level was inversely associated with physical HR-QOL in Korean pre-dialysis CKD patients. This relationship was independent of various cardiovascular risk factors.
高 adiponectin 血症与慢性肾脏病（CKD）患者的肾脏疾病进展和死亡率呈矛盾相关。其与健康相关生活质量（HR-QOL）的关系尚不清楚。本研究旨在验证韩国透析前 CKD 队列中 adiponectin 与 HR-QOL 的相关性。本横断面研究分析了 KNOW-CKD（韩国慢性肾脏病患者结局研究）中的 1551 例透析前 CKD 患者。根据 adiponectin 水平将参与者分为三组（T1-T3）。使用 SF-36 评估 HR-QOL。高生理成分综合评分（PCS）和心理成分综合评分（MCS）定义为每个评分的最高四分位数。采用多变量逻辑回归分析高 PCS 和 MCS 的比值比（OR）和 95%置信区间（CI）。高 PCS 的患病率分别为 33.3%、27.5%和 17.0%，高 MCS 的患病率分别为 31.7%、24.8%和 21.3%，T1、T2 和 T3 均呈趋势性差异（均 p<0.001）。与 T3 相比，T1 和 T2 的调整后 OR[95%CI]分别为 1.56[1.09-2.23]和 1.19[0.85-1.68]，用于高 PCS，1.19[0.85-1.68]和 0.94[0.68-1.29]用于高 MCS。血清 adiponectin 水平与韩国透析前 CKD 患者的生理 HR-QOL 呈负相关。这种关系独立于各种心血管危险因素。
