Head of Orthodontic Department, Sindh Institute of Oral Health Sciences, Jinnah Sindh Medical University, Karachi, Pakistan.
Orthodontic Department, College of Dentistry, Jouf University, Sakaka 72721, Aljouf, Saudi Arabia.
Pain Res Manag. 2021 May 5;2021:6624723. doi: 10.1155/2021/6624723. eCollection 2021.
Low-intensity pulsed ultrasound (LIPUS) is a noninvasive modality to stimulate bone remodeling (BR) and the healing of hard and soft tissues. This research evaluates the biostimulatory effect of LIPUS on the rate of orthodontic tooth movement (OTM) and associated pain, when applied at 3-week intervals.
Twenty-two patients (11 males and 11 females; mean age 19.18 ± 2.00 years) having Angle's Class II division 1 malocclusion needing bilateral extractions of maxillary first bicuspids were recruited for this split-mouth randomized clinical trial. After the initial stage of alignment and leveling with contemporary edgewise MBT (McLaughlin-Bennett-Trevisi) prescription brackets (Ortho Organizers, Carlsbad, Calif) of 22 mil, followed by extractions of premolars bilaterally, 6 mm nickel-titanium spring was used to retract the canines separately by applying 150 g force on 0.019 × 0.025-in stainless steel working archwires. LIPUS (1.1 MHz frequency and 30 mW/cm intensity output) was applied for 20 minutes extraorally and reapplied after 3 weeks for 2 more successive visits over the root of maxillary canine on the experimental side whereas the other side was placebo. A numerical rating scale- (NRS-) based questionnaire was given to the patients on each visit to record their weekly pain experience. Impressions were also made at each visit before the application of LIPUS (T1, T2, and T3). Models were scanned with a CAD/CAM scanner (Planmeca, Helsinki, Finland). Mann-Whitney test was applied for comparison of canine movement and pain intensity between both the groups.
No significant difference in the rate of canine movement was found among the experimental (0.90 mm ± 0.33 mm) and placebo groups (0.81 mm ± 0.32 mm). There was no difference in pain reduction between experimental and placebo groups ( > 0.05).
Single-dose application of LIPUS at 3-week intervals is ineffective in stimulating the OTM and reducing associated treatment pain.
低强度脉冲超声（LIPUS）是一种非侵入性的方式，可以刺激骨重塑（BR）和硬组织和软组织的愈合。本研究评估了 LIPUS 在 3 周间隔应用时对正畸牙齿移动（OTM）速度和相关疼痛的生物刺激作用。
招募了 22 名（11 名男性和 11 名女性；平均年龄 19.18±2.00 岁）患有安氏 II 类 1 分类错颌需要上颌第一双尖牙双侧拔牙的患者进行这项分口随机临床试验。在使用当代边缘型 MBT（McLaughlin-Bennett-Trevisi）方丝弓（Ortho Organizers，Carlsbad，CA）22 密尔后进行初始阶段的排齐和整平，随后双侧拔除前磨牙，使用 6mm 镍钛弹簧分别将尖牙向后牵拉，在 0.019×0.025 英寸不锈钢工作弓丝上施加 150g 的力。LIPUS（1.1MHz 频率和 30mW/cm 强度输出）在实验侧上颌尖牙根部额外应用 20 分钟，3 周后再应用 2 次，共连续 3 次就诊。在每次就诊时，患者都使用基于数字评分量表（NRS）的问卷记录他们每周的疼痛体验。在每次就诊前，也在 LIPUS 应用前进行印模（T1、T2 和 T3）。模型用 CAD/CAM 扫描仪（Planmeca，Helsinki，Finland）扫描。应用 Mann-Whitney 检验比较两组间的尖牙移动和疼痛强度。
实验组（0.90mm±0.33mm）和对照组（0.81mm±0.32mm）的尖牙移动率无显著差异。实验组和对照组的疼痛减轻程度无差异（>0.05）。
3 周间隔单次应用 LIPUS 对刺激 OTM 和减轻相关治疗疼痛无效。
