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经皮立体定向电化学治疗不可切除肝门部大 HCC 的初步探索

Stereotactic Percutaneous Electrochemotherapy as Primary Approach for Unresectable Large HCC at the Hepatic Hilum.

机构信息

Department of Radiology, University Hospital Regensburg, Franz-Josef-Strauss-Allee 11, 93053, Regensburg, Germany.

Faculty of Medicine, Department of Diagnostic and Interventional Radiology, Medical Center, University of Freiburg, Hugstetter Straße 55, 79106, Freiburg, Germany.

出版信息

Cardiovasc Intervent Radiol. 2021 Sep;44(9):1462-1466. doi: 10.1007/s00270-021-02841-1. Epub 2021 May 25.

DOI:10.1007/s00270-021-02841-1
PMID:34036404
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8382613/
Abstract

Electrochemotherapy (ECT) is a novel non-thermal ablative technique that combines chemotherapy and the application of electric pulses for reversible cell membrane electroporation. This method was recently performed in the treatment of deep-seated liver tumors during open surgery but experience about percutaneous ECT is rare and further developments like combination of percutaneous ECT with stereotactic navigated devices may be very promising. We report on a case of a 4.7 × 4.5 × 3.5 cm unresectable HCC at the hepatic hilum adjacent to the major vessels and the bile duct that was successfully treated using percutaneous ECT in combination with stereotactic navigation. Follow-up imaging 6 weeks and 6 months after ECT showed complete response.

摘要

电化学治疗（ECT）是一种新的非热消融技术，它将化疗和电脉冲应用于可逆的细胞膜电穿孔。该方法最近已应用于开放性手术中治疗深部肝脏肿瘤，但经皮 ECT 的经验很少，而经皮 ECT 与立体定向导航设备相结合等进一步发展可能非常有前途。我们报告了一例位于肝门附近主要血管和胆管旁、大小为 4.7×4.5×3.5cm 的不可切除 HCC，成功地使用经皮 ECT 联合立体定向导航进行了治疗。ECT 后 6 周和 6 个月的随访影像学检查显示完全缓解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52cd/8382613/5b0da81de872/270_2021_2841_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52cd/8382613/4d23a19e5fcb/270_2021_2841_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52cd/8382613/6ec8c8de7498/270_2021_2841_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52cd/8382613/5b0da81de872/270_2021_2841_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52cd/8382613/4d23a19e5fcb/270_2021_2841_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52cd/8382613/6ec8c8de7498/270_2021_2841_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/52cd/8382613/5b0da81de872/270_2021_2841_Fig3_HTML.jpg

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Therap Adv Gastroenterol. 2019 Aug 21;12:1756284819862966. doi: 10.1177/1756284819862966. eCollection 2019.
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Stereotactically navigated percutaneous microwave ablation (MWA) compared to conventional MWA: a matched pair analysis.
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Bioengineering (Basel). 2023 Aug 18;10(8):975. doi: 10.3390/bioengineering10080975.
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Safety and Feasibility of Analgosedation for Electrochemotherapy of Liver Lesions.肝损伤电化学疗法中镇痛镇静的安全性与可行性
Life (Basel). 2023 Feb 24;13(3):631. doi: 10.3390/life13030631.
立体定向导航经皮微波消融（MWA）与传统 MWA 的比较：配对分析。
Int J Comput Assist Radiol Surg. 2018 Dec;13(12):1991-1997. doi: 10.1007/s11548-018-1778-7. Epub 2018 May 4.
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