耐药性癫痫患者中白细胞介素-10、干扰素-γ及硫醇-二硫化物稳态的评估
Evaluation of IL-10, IFN-γ, and thiol-disulfide homeostasis in patients with drug-resistant epilepsy.
作者信息
Kocatürk Mehtap, Kirmit Adnan
机构信息
Department of Neurology, Balikesir University, Pasakoy, Bigadic yolu üzeri Merkez/Altıeylul/Balikesir, 10145, Balıkesir, Turkey.
Department of Biochemistry, Harran University, Sanlıurfa, Turkey.
出版信息
Neurol Sci. 2022 Jan;43(1):485-492. doi: 10.1007/s10072-021-05331-x. Epub 2021 May 25.
AIM
This study compared dynamic thiol-disulfide homeostasis (an oxidative stress marker), anti-inflammatory interleukin-10 (IL-10) levels, and proinflammatory interferon gamma (IFN-γ) levels in drug-resistant epilepsy patients with those in patients with well-controlled epilepsy and healthy controls.
METHOD
This prospective cross-sectional study enrolled 89 people: 27 with drug-resistant epilepsy, 30 with well-controlled epilepsy, and 32 healthy controls matched in demographic characteristics.
RESULTS
The mean serum IL-10 levels were significantly lower and the mean serum IFN-γ levels significantly higher in the drug-resistant epilepsy patients compared to the well-controlled epilepsy and healthy control groups. The mean serum native thiol (SH) and total thiol (TT) levels were significantly lower, and the disulfide (SS) levels were significantly higher in the drug-resistant group than in the other two groups.
CONCLUSIONS
The significant differences in thiol-disulfide homeostasis and IL-10 and IFN-γ levels in the drug-resistant epilepsy group suggest that these markers indicate a poor prognosis in epilepsy.
目的
本研究比较了耐药性癫痫患者与癫痫控制良好的患者及健康对照者之间的动态硫醇 - 二硫键稳态（一种氧化应激标志物）、抗炎性白细胞介素 - 10（IL - 10）水平和促炎性干扰素γ（IFN - γ）水平。
方法
这项前瞻性横断面研究纳入了89人：27例耐药性癫痫患者、30例癫痫控制良好的患者以及32名在人口统计学特征上相匹配的健康对照者。
结果
与癫痫控制良好的患者组和健康对照组相比，耐药性癫痫患者的血清IL - 10平均水平显著降低，血清IFN - γ平均水平显著升高。耐药组的血清天然硫醇（SH）和总硫醇（TT）平均水平显著降低以及二硫键（SS）水平显著高于其他两组。
结论
耐药性癫痫组中硫醇 - 二硫键稳态以及IL - 10和IFN - γ水平的显著差异表明，这些标志物提示癫痫预后不良。
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