假性剥脱综合征中的硫醇二硫键稳态
Thiol Disulfide Homeostasis in Pseudoexfoliation Syndrome.
作者信息
Tetikoğlu Mehmet, Aktas Serdar, Sağdik Haci Murat, Özcura Fatih, Uçar Fatma, Koçak Havva, Neşelioğlu Salim, Erel Özcan
机构信息
a Department of Ophthalmology , Dumlupinar University School of Medicine , Kutahya , Turkey.
b Department of Biochemistry , Dışkapı Yıldırım Beyazit Training and Research Hospital , Ankara , Turkey.
出版信息
Curr Eye Res. 2017 Jun;42(6):876-879. doi: 10.1080/02713683.2016.1256412. Epub 2017 Jan 13.
PURPOSE
To determine the serum thiol disulfide homeostasis in patients with pseudoexfoliation (PEX) syndrome.
METHOD
Thirty-five patients with PEX syndrome and forty healthy subjects were included in this observational case-control study. Serum native thiol, total thiol, disulfide, and native thiol/disulfide ratio were determined using a novel and automated assay.
RESULTS
The mean serum total thiol and native thiol levels were significantly lower in patients with PEX syndrome compared to healthy controls (p = 0.001). The mean serum disulfide level was significantly higher in patients with PEX syndrome compared to healthy controls (p = 0.023). The serum native thiol/disulfide ratio was lower in patients with PEX syndrome compared to healthy subjects (16 ± 10.1 vs 22.3 ± 11.5, respectively, p = 0.014).
CONCLUSION
Our findings provide evidence that the dynamic native thiol/disulfide ratio is lower in PEX syndrome, which shows a reduction in the natural cell reductive capacity reservoir.
目的
确定假性剥脱（PEX）综合征患者的血清硫醇二硫键内稳态。
方法
本观察性病例对照研究纳入了35例PEX综合征患者和40名健康受试者。使用一种新型自动化检测方法测定血清天然硫醇、总硫醇、二硫键以及天然硫醇/二硫键比值。
结果
与健康对照相比，PEX综合征患者的血清总硫醇和天然硫醇平均水平显著降低（p = 0.001）。与健康对照相比，PEX综合征患者的血清二硫键平均水平显著升高（p = 0.023）。与健康受试者相比，PEX综合征患者的血清天然硫醇/二硫键比值更低（分别为16±10.1和22.3±11.5，p = 0.014）。
结论
我们的研究结果表明，PEX综合征患者动态天然硫醇/二硫键比值较低，这表明天然细胞还原能力储备降低。
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