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紫外线诱导的光老化对C57BL6/J小鼠毛囊周期的影响

Effects of UV Induced-Photoaging on the Hair Follicle Cycle of C57BL6/J Mice.

作者信息

Zhai Xu, Gong Meihua, Peng Yixuan, Yang Daping

机构信息

Department of Plastic Surgery, The 2nd Hospital of Harbin Medical University, Harbin, People's Republic of China.

Department of Plastic and Cosmetic Surgery, Shenzhen People's Hospital, Second Affiliated Hospital of Jinan University Medical College, Shenzhen, People's Republic of China.

出版信息

Clin Cosmet Investig Dermatol. 2021 May 18;14:527-539. doi: 10.2147/CCID.S310487. eCollection 2021.

DOI:10.2147/CCID.S310487
PMID:34040410
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8140904/
Abstract

PURPOSE

To study the changes in the hair follicle cycle and related stem cells induced by photoaging to establish a mouse model of senescence in hair follicles.

METHODS

There were 54 C57BL6/J mice randomly divided into three groups. The UVA group and the UVB group underwent photoaging induced by UV lamps for 8 weeks. Changes in skin and the hair follicle cycle were compared by physical signs, dermoscopy, and hematoxylin and eosin and Masson's staining in each group. Western blot, immunohistochemistry, and RT-qPCR were carried out to test canonical proteins and gene expression of the Wnt signaling pathway in the samples. Immunofluorescence was chosen to show variations in the stem cells related to the hair follicle cycle.

RESULTS

There were more gray hairs in the UVA group than the other groups (P<0.05). Both diameter of the hair shaft and depth of hair root were significantly decreased in the UV groups (P<0.05). Stem cells and melanocytes of the hair follicles were reduced in the UVA group. UV, especially UVB, up-regulated the expression of the Wnt signaling pathway and prolonged anagen and telogen phases in the hair follicles, compared with the control group (P<0.05).

CONCLUSION

By decreasing the number of stem cells related to hair follicles, UVA induces hair follicle photoaging characterized by hair follicle miniaturization and gray hairs. UV up-regulated the expression of the Wnt signaling pathway, and the hair follicle cycle was significantly prolonged by UVB.

摘要

目的

研究光老化诱导的毛囊周期及相关干细胞变化，建立毛囊衰老小鼠模型。

方法

将54只C57BL6/J小鼠随机分为三组。UVA组和UVB组用紫外线灯诱导光老化8周。通过体征、皮肤镜检查以及苏木精-伊红染色和Masson染色比较各组皮肤和毛囊周期的变化。采用蛋白质免疫印迹法、免疫组织化学法和逆转录-定量聚合酶链反应检测样本中Wnt信号通路的典型蛋白和基因表达。选择免疫荧光法显示与毛囊周期相关的干细胞变化。

结果

UVA组的灰发比其他组更多（P<0.05）。UV组的毛干直径和发根深度均显著降低（P<0.05）。UVA组毛囊干细胞和黑素细胞减少。与对照组相比，紫外线，尤其是UVB，上调了Wnt信号通路的表达，延长了毛囊的生长期和休止期（P<0.05）。

结论

UVA通过减少毛囊相关干细胞数量，诱导以毛囊小型化和灰发为特征的毛囊光老化。紫外线上调Wnt信号通路的表达，UVB显著延长毛囊周期。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84ba/8140904/07629f3b18a4/CCID-14-527-g0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84ba/8140904/ce1578f2a720/CCID-14-527-g0001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84ba/8140904/f6d8a142f741/CCID-14-527-g0007.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84ba/8140904/5216cf0a398c/CCID-14-527-g0003.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84ba/8140904/505f7f63544f/CCID-14-527-g0005.jpg
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