Zaheer Arsalan, Zaheer Faizan, Saeed Hadia, Tahir Zoya, Tahir Muhammad Waqas
Medicine, Gujrat Hospital, Gujrat, PAK.
Medicine, Fatima Memorial Hospital College of Medicine and Dentistry, Lahore, PAK.
Cureus. 2021 Apr 21;13(4):e14600. doi: 10.7759/cureus.14600.
Currently there is no recognized curative treatment for diabetic polyneuropathy (DPN). Strict glucose control and symptomatic pain relief are the first line management routes. DPN is a common complication of diabetes and has a major detrimental influence on the quality of life (QOL) for many patients. Due to the scope of the problem, it is imperative that treatment options which impede DPN's progression and restore sensorineural function should be researched comprehensively and made available to the masses at an economical cost. We reviewed a multitude of atypical treatment options for DPN including capsaicin, lidocaine, acupuncture, electrical nerve stimulation, alpha lipoic acid, benfotiamine, and acetyl-l-carnitine and explored the evidence to date regarding their safety and efficacy. Most of these options have been around for a long time and have promising pilot studies or small-scale trials focused on DPN treatment.
目前，糖尿病性多发性神经病变（DPN）尚无公认的治愈性治疗方法。严格控制血糖和缓解症状性疼痛是一线治疗途径。DPN是糖尿病的常见并发症，对许多患者的生活质量（QOL）有重大不利影响。鉴于该问题的范围，必须全面研究能够阻止DPN进展并恢复感觉神经功能的治疗选择，并以经济的成本提供给大众。我们回顾了多种针对DPN的非典型治疗选择，包括辣椒素、利多卡因、针灸、电神经刺激、α硫辛酸、苯磷硫胺和乙酰左旋肉碱，并探讨了迄今为止关于它们安全性和有效性的证据。这些选择大多已经存在很长时间，并且有专注于DPN治疗的有前景的初步研究或小规模试验。
