Akter Shamima, Choubey Mayank, Mohib Mohammad Mohabbulla, Arbee Shahida, Sagor Md Abu Taher, Mohiuddin Mohammad Sarif
Department of Internal Medicine, St. Francis-Emory Healthcare, 2122 Manchester Expressway, Columbus, GA 31904, USA.
Department of Foundations of Medicine, NYU Long Island School of Medicine, 101 Mineola Blvd, Mineola, NY 11501, USA.
Brain Sci. 2023 Feb 2;13(2):255. doi: 10.3390/brainsci13020255.
Diabetic polyneuropathy (DPN) is the most frequent, although neglected, complication of long-term diabetes. Nearly 30% of hospitalized and 20% of community-dwelling patients with diabetes suffer from DPN; the incidence rate is approximately 2% annually. To date, there has been no curable therapy for DPN. Under these circumstances, cell therapy may be a vital candidate for the treatment of DPN. The epidemiology, classification, and treatment options for DPN are disclosed in the current review. Cell-based therapies using bone marrow-derived cells, embryonic stem cells, pluripotent stem cells, endothelial progenitor cells, mesenchymal stem cells, or dental pulp stem cells are our primary concern, which may be a useful treatment option to ease or to stop the progression of DPN. The importance of cryotherapies for treating DPN has been observed in several studies. These findings may help for the future researchers to establish more focused, accurate, effective, alternative, and safe therapy to reduce DPN. Cell-based therapy might be a permanent solution in the treatment and management of diabetes-induced neuropathy.
糖尿病性多发性神经病变（DPN）是长期糖尿病最常见但却被忽视的并发症。近30%的住院糖尿病患者以及20%的社区糖尿病患者患有DPN；其发病率约为每年2%。迄今为止，尚无治愈DPN的疗法。在这种情况下，细胞疗法可能是治疗DPN的重要选择。本综述阐述了DPN的流行病学、分类及治疗选择。使用骨髓来源细胞、胚胎干细胞、多能干细胞、内皮祖细胞、间充质干细胞或牙髓干细胞的细胞疗法是我们主要关注的内容，其可能是缓解或阻止DPN进展的一种有效治疗选择。多项研究已观察到冷冻疗法对治疗DPN的重要性。这些发现可能有助于未来的研究人员建立更具针对性、准确、有效、替代且安全的疗法以减轻DPN。细胞疗法可能是治疗和管理糖尿病性神经病变的永久性解决方案。
