Gebeyehu Daniel Teshome
Department of Veterinary Medicine, School of Veterinary Medicine, Wollo University, Dessie, Ethiopia.
Vet Med (Auckl). 2021 May 18;12:101-108. doi: 10.2147/VMRR.S310169. eCollection 2021.
In recent years, an increase in the development of antimicrobial-resistant pathogens especially foodborne zoonotic bacteria has been observed. As a result, crude mortality rates are increasing due to those resistant bacteria in both human and animal populations, particularly in developing countries like Tanzania where the risk of infection is high due to poor biosecurity measures, close animal-human interactions, and extensive use of antimicrobials for animal productions. One of those zoonotic bacterial pathogens, which commonly contaminates food, is .
A cross-sectional study was carried out on samples collected from diarrheic sheep, to assess the level of antibiotic resistance of . From 165 fecal samples, 80 of which were tested positive for . The antibiotic resistance level of isolates was conducted by the Kirby-Bauer disc diffusion method using ten commonly used antibiotics in the study area.
Out of 80 positive samples, all (100%) of them were resistant to amoxicillin and ampicillin while sixty-eight (85%), 68 (85%), and 60 (75%) isolates were susceptible to gentamicin, ciprofloxacin, and kanamycin, respectively. Thirty (37.5%) isolates were resistant to both trimethoprim and tetracycline and 25% of the isolates were resistant to both doxycycline and chloramphenicol while 12.5% of the isolates were resistant to nalidixic acid.
This study revealed that the isolates of diarrheic sheep developed a wide range of resistance to different antibiotics. Further studies and integrative approaches in a one health framework among animal-human and environmental health professionals are recommended for the mitigation of health risks arising from antibiotic-resistant zoonotic pathogens like .
近年来，已观察到抗菌药物耐药性病原体尤其是食源性人畜共患病细菌的发展有所增加。因此，由于这些耐药细菌，人类和动物群体中的粗死亡率都在上升，特别是在坦桑尼亚等发展中国家，由于生物安全措施差、动物与人类密切互动以及在动物生产中广泛使用抗菌药物，感染风险很高。其中一种常见污染食物的人畜共患病细菌病原体是……
对从腹泻绵羊采集的样本进行了横断面研究，以评估……的抗生素耐药水平。从165份粪便样本中，其中80份检测出……呈阳性。使用研究区域常用的十种抗生素，通过 Kirby-Bauer 纸片扩散法对……分离株的抗生素耐药水平进行了检测。
在80份……阳性样本中，所有样本（100%）都对阿莫西林和氨苄西林耐药，而分别有68株（85%）、68株（85%）和60株（75%）分离株对庆大霉素、环丙沙星和卡那霉素敏感。30株（37.5%）……分离株对甲氧苄啶和四环素都耐药，25%的分离株对强力霉素和氯霉素都耐药，而12.5%的分离株对萘啶酸耐药。
本研究表明，腹泻绵羊的……分离株对不同抗生素产生了广泛耐药性。建议动物、人类和环境卫生专业人员在“同一健康”框架下开展进一步研究和综合方法，以减轻像……这样的抗生素耐药性人畜共患病原体带来的健康风险。
