Patil Shashank M, Ramu Ramith, Shirahatti Prithvi S, Shivamallu Chandan, Amachawadi Raghavendra G
Department of Biotechnology and Bioinformatics, School of Life Sciences, JSS Academy of Higher Education and Research, Mysuru, 570 015, Karnataka, India.
Department of Biotechnology, Teresian College, Siddhartha Nagara, Mysuru, 570 011, Karnataka, India.
Heliyon. 2021 May 18;7(5):e07054. doi: 10.1016/j.heliyon.2021.e07054. eCollection 2021 May.
Linn. is a medicinal and culinary herb from the Southern European region known for its anti-infective, cardioprotective, gastroprotective, anti-inflammatory, and immunomodulatory activities since the Egyptian era. The reported pharmacological activities of L. include antibacterial, antioxidant, anti-inflammatory, antiviral, and anti-cancerous activities. In this review, a comprehensive approach is put forth to scrutinize and report the available data on phytochemistry, ethnopharmacology, pharmacology, and toxicology of the plant. The different extracts and essential oil obtained from the plant have been assessed and reported to treat ailments like microbial infections, inflammation, non-communicable diseases like cancer, and sexually transmitted diseases like HIV-1 and Herpes. The literature review has also indicated the use of volatile oils, phenolic acids, terpenoids, flavonoids, saponins, steroids, tannins, alkaloids, and polysaccharides in pharmacotherapy. Applications of these compounds including antidiabetic, anti-Alzheimer's, cardio, neuro and hepatoprotective, anti-osteoporosis, sedative, immunomodulatory, antioxidant, anti-tyrosinase, antispasmodic, antinociceptive, gastroprotective, anticonvulsant, antihypertensive, antidepressant, anti-amnesia, and anti-helminthic activities have been mentioned. Further, based on research gaps, recommendations have been provided to evaluate L. systematically to develop plant-based drugs, nutraceuticals, and to evaluate their clinical efficiency and safety.
自埃及时代起，[植物名称（原文未给出具体中文名）] Linn. 就是一种来自南欧地区的药食两用草本植物，以其抗感染、心脏保护、胃保护、抗炎和免疫调节活性而闻名。该植物已报道的药理活性包括抗菌、抗氧化、抗炎、抗病毒和抗癌活性。在本综述中，提出了一种综合方法来审查和报告有关该植物植物化学、民族药理学、药理学和毒理学的现有数据。已对从该植物中获得的不同提取物和精油进行了评估，并报告其可治疗诸如微生物感染、炎症、癌症等非传染性疾病以及HIV-1和疱疹等性传播疾病等疾病。文献综述还表明挥发油、酚酸、萜类、黄酮类、皂苷、甾体、单宁、生物碱和多糖在药物治疗中的应用。这些化合物的应用包括抗糖尿病、抗阿尔茨海默病、心脏保护、神经保护和肝脏保护、抗骨质疏松、镇静、免疫调节、抗氧化、抗酪氨酸酶、解痉、抗伤害感受、胃保护、抗惊厥、抗高血压、抗抑郁、抗失忆和抗蠕虫活性等均有提及。此外，基于研究空白，已提供建议以系统评估[植物名称（原文未给出具体中文名）]，以开发植物源药物、营养保健品，并评估其临床疗效和安全性。
