Medicinal Plants Processing Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
Department of Phytopharmaceuticals (Traditional Pharmacy), School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
Phytother Res. 2021 Sep;35(9):5031-5052. doi: 10.1002/ptr.7134. Epub 2021 May 27.
Depression is one of the most common mental disorders worldwide. The genetic factors are linked to depression and anti-depressant outcomes. Traditional Persian medicine (TPM) manuscripts have provided various anti-depressant remedies, which may be useful in depression management. This review has studied the bioactive compounds, underlying mechanisms, and treatment outcomes of the medicinal plants traditionally mentioned effective for depression from "The storehouse of medicament" (a famous pharmacopeia of TPM) to merge those with the novel genetics science and serve new scope in depression prevention and management. This review paper has been conducted in two sections: (1) Collecting medicinal plants and their bioactive components from "The storehouse of medicament," "Physician's Desk Reference (PDR) for Herbal Medicines," and "Google scholar" database. (2) The critical key factors and genes in depression pathophysiology, prevention, and treatment were clarified. Subsequently, the association between bioactive components' underlying mechanism and depression treatment outcomes via considering polymorphisms in related genes was derived. Taken together, α-Mangostin, β-carotene, β-pinene, apigenin, caffeic acid, catechin, chlorogenic acid, citral, ellagic acid, esculetin, ferulic acid, gallic acid, gentiopicroside, hyperoside, kaempferol, limonene, linalool, lycopene, naringin, protocatechuic acid, quercetin, resveratrol, rosmarinic acid, and umbelliferone are suitable for future pharmacogenetics-based studies in the management of depression.
抑郁症是全球最常见的精神障碍之一。遗传因素与抑郁症和抗抑郁药的疗效有关。传统的波斯医学（TPM）手稿提供了各种抗抑郁的治疗方法，这些方法可能对抑郁症的管理有用。本综述研究了传统上被认为对抑郁症有效的药用植物的生物活性化合物、潜在机制和治疗效果，这些植物来自于“医药宝库”（TPM 的著名药典），并将其与新的遗传学科学相结合，为抑郁症的预防和管理提供了新的方向。本文综述分两部分进行：（1）从“医药宝库”、“医师案头参考（PDR）草药学”和“谷歌学术”数据库中收集药用植物及其生物活性成分。（2）阐明了抑郁症病理生理学、预防和治疗的关键因素和基因。随后，考虑到相关基因的多态性，推导出了生物活性成分潜在机制与抑郁症治疗效果之间的关系。总的来说，α-倒捻子素、β-胡萝卜素、β-蒎烯、芹菜素、咖啡酸、儿茶素、绿原酸、柠檬醛、鞣花酸、esculetin、阿魏酸、没食子酸、龙胆苦苷、金丝桃苷、槲皮素、柠檬烯、芳樟醇、番茄红素、柚皮苷、原儿茶酸、槲皮素、白藜芦醇、迷迭香酸和茴芹内酯适合未来基于药物遗传学的抑郁症管理研究。
