Kooistra C A, Heilman K M
Department of Neurology, College of Medicine, University of Florida, Gainesville.
J Neurol Neurosurg Psychiatry. 1988 Jun;51(6):866-9. doi: 10.1136/jnnp.51.6.866.
Clinical disorders of memory are believed to occur from the dysfunction of either the mesial temporal lobe, the mesial thalamus, or the basal forebrain. Fibre tract damage at the level of the fornix has only inconsistently produced amnesia. A patient is reported who suffered a cerebrovascular accident involving the posterior limb of the left internal capsule that resulted in a persistent and severe disorder of verbal memory. The inferior extent of the lesion effectively disconnected the mesial thalamus from the amygdala and the frontal cortex by disrupting the ventral amygdalofugal and thalamic-frontal pathways as they course through the diencephalon. This case demonstrates that an isolated lesion may cause memory loss without involvement of traditional structures associated with memory and may explain memory disturbances in other white matter disease such as multiple sclerosis and lacunar state.
记忆的临床障碍被认为是由内侧颞叶、内侧丘脑或基底前脑的功能障碍引起的。穹窿水平的纤维束损伤仅偶尔导致失忆。本文报告了一名患者，其发生涉及左侧内囊后肢的脑血管意外，导致持续性严重言语记忆障碍。病变的下延通过破坏腹侧杏仁体传出通路和丘脑 - 额叶通路在间脑的走行，有效地使内侧丘脑与杏仁核和额叶皮质断开连接。该病例表明，孤立的病变可能导致记忆丧失，而无需涉及与记忆相关的传统结构，并且可以解释其他白质疾病（如多发性硬化症和腔隙状态）中的记忆障碍。
