United States Food and Drug Administration, Center for Veterinary Medicine, Office of Research, Veterinary Laboratory Investigation and Response Network, Laurel, MD.
United States Food and Drug Administration, Center for Veterinary Medicine, Office of Surveillance and Compliance, Rockville, MD.
Top Companion Anim Med. 2021 Aug;44:100548. doi: 10.1016/j.tcam.2021.100548. Epub 2021 May 24.
Four previously healthy adult domestic shorthair cats (2 male, 2 female) from one household developed acute vomiting and ataxia less than 12 hours after consuming a commercial canned cat food. Blood work abnormalities included mild hyperglycemia with increased alanine aminotransferase (n = 1) and decreased blood urea nitrogen (n = 2). The veterinarian conducted whole blood ethylene glycol (EG) tests, which were positive for all cats. There were no known EG exposures. All cats were treated for suspected EG toxicosis and fully recovered after 48 hours. Separately from the cats' case, the same food was voluntarily recalled by the manufacturer 5 days later due to a higher-than-formulated amount of choline chloride added to the food. The 4 cats' canned cat food was tested for choline, choline chloride, EG, diethylene glycol, and propylene glycol to look for causes of the positive whole blood EG test. The cat food contained an average of 165,300 ppm (165,300 mg/kg) choline and 221,600 ppm (221,600 mg/kg) choline chloride on a dry matter basis, which is at least 65 times the recommended choline amount for adult cats. No glycols were detected. This case documents suspected choline toxicosis in cats after consuming a commercial canned cat food with a higher-than-formulated amount of choline chloride, and it suggests that choline toxicosis may cause a positive result on some EG whole blood tests. Choline toxicosis could be a possible differential diagnosis when a cat has a positive EG test and no known exposure to antifreeze.
四只先前健康的成年家养短毛猫（2 雄，2 雌）来自同一家庭，在食用一种商业罐装猫粮后不到 12 小时出现急性呕吐和共济失调。血液检查异常包括轻度高血糖伴丙氨酸氨基转移酶升高（n=1）和血尿素氮降低（n=2）。兽医进行了全血乙二醇（EG）检测，所有猫的检测结果均为阳性。没有已知的 EG 暴露。所有猫都被怀疑 EG 中毒进行了治疗，在 48 小时后完全康复。与猫的病例分开，同一种食物在 5 天后因添加到食物中的氯化胆碱含量高于配方而被制造商自愿召回。对 4 只猫的罐装猫粮进行了胆碱、氯化胆碱、EG、二甘醇和丙二醇检测，以寻找全血 EG 检测呈阳性的原因。这种猫粮以干物质为基础，平均含有 165300ppm（165300mg/kg）胆碱和 221600ppm（221600mg/kg）氯化胆碱，至少是成年猫推荐胆碱量的 65 倍。没有检测到二醇。本病例记录了猫在食用一种商业罐装猫粮后出现疑似胆碱中毒，这种猫粮中添加的氯化胆碱超过配方量，这表明胆碱中毒可能导致某些 EG 全血检测呈阳性。当猫的 EG 检测呈阳性且没有已知的防冻剂暴露时，胆碱中毒可能是一种可能的鉴别诊断。
