[间充质干细胞来源外泌体在伤口愈合及增生性瘢痕防治中的作用研究进展]
[Research advances on the roles of exosomes derived from mesenchymal stem cells in wound healing and prevention and treatment of hypertrophic scars].
作者信息
Sun J, Shi C S, Wang D L
机构信息
Department of Burns and Plastic Surgery, the Affiliated Hospital of Zunyi Medical University, Zunyi 563003, China.
出版信息
Zhonghua Shao Shang Za Zhi. 2021 May 20;37(5):495-500. doi: 10.3760/cma.j.cn501120-20200410-00220.
Abstract
Skin is an important defense barrier of human body and one of the most vulnerable organs. Wounds are the result of damage to the integrity of skin. Chronic wounds and hypertrophic scar formation are the results of abnormal wound healing, and are also the clinical problems those need to be resolved urgently in the field of wound repair. In recent years, researchers have found that mesenchymal stem cells (MSCs) can promote wound healing, improve wound healing quality, and reduce scar formation. The therapeutic effect of MSCs may be derived from the exosomes derived from them. This paper reviews the research advances of exosomes derived from MSCs in wound healing and prevention and treatment of hypertrophic scars in recent years and looks up to the prospect for the clinical application.
摘要
皮肤是人体重要的防御屏障，也是最易受损的器官之一。伤口是皮肤完整性受损的结果。慢性伤口和瘢痕疙瘩形成是伤口愈合异常的结果，也是伤口修复领域亟待解决的临床问题。近年来，研究人员发现间充质干细胞（MSCs）可促进伤口愈合、提高伤口愈合质量并减少瘢痕形成。MSCs的治疗作用可能源于其分泌的外泌体。本文综述了近年来MSCs来源外泌体在伤口愈合及瘢痕疙瘩防治方面的研究进展，并展望其临床应用前景。
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本文引用的文献
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Front Pharmacol. 2019 Nov 14;10:1368. doi: 10.3389/fphar.2019.01368. eCollection 2019.
2
Macrophage-derived exosomes accelerate wound healing through their anti-inflammation effects in a diabetic rat model.巨噬细胞衍生的外泌体通过其在糖尿病大鼠模型中的抗炎作用加速伤口愈合。
Artif Cells Nanomed Biotechnol. 2019 Dec;47(1):3793-3803. doi: 10.1080/21691401.2019.1669617.
3
Efficient Angiogenesis-Based Diabetic Wound Healing/Skin Reconstruction through Bioactive Antibacterial Adhesive Ultraviolet Shielding Nanodressing with Exosome Release.高效血管生成的糖尿病创面愈合/皮肤重建：基于具有外泌体释放功能的生物活性抗菌黏附型紫外屏蔽纳米敷料。
ACS Nano. 2019 Sep 24;13(9):10279-10293. doi: 10.1021/acsnano.9b03656. Epub 2019 Sep 9.
4
Grape Seed-Inspired Smart Hydrogel Scaffolds for Melanoma Therapy and Wound Healing.葡萄籽启发的智能水凝胶支架用于黑素瘤治疗和伤口愈合。
ACS Nano. 2019 Apr 23;13(4):4302-4311. doi: 10.1021/acsnano.8b09496. Epub 2019 Apr 3.
5
Delivery of miR-675 by stem cell-derived exosomes encapsulated in silk fibroin hydrogel prevents aging-induced vascular dysfunction in mouse hindlimb.丝素蛋白水凝胶包裹的干细胞衍生外泌体递送 miR-675 可预防小鼠后肢衰老引起的血管功能障碍。
Mater Sci Eng C Mater Biol Appl. 2019 Jun;99:322-332. doi: 10.1016/j.msec.2019.01.122. Epub 2019 Jan 28.
6
Exosomes: biogenesis, biologic function and clinical potential.外泌体：生物发生、生物学功能及临床应用潜力
Cell Biosci. 2019 Feb 15;9:19. doi: 10.1186/s13578-019-0282-2. eCollection 2019.
7
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8
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