Zhang Miao, Qiao Xiaoni, Han Wenwei, Jiang Tianze, Liu Fei, Zhao Xia
Key Laboratory of Marine Drugs, Ministry of Education, Shandong Provincial Key Laboratory of Glycoscience and Glycoengineering, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China; Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology, Qingdao 266237, China.
Key Laboratory of Marine Drugs, Ministry of Education, Shandong Provincial Key Laboratory of Glycoscience and Glycoengineering, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.
Carbohydr Polym. 2021 Aug 15;266:118100. doi: 10.1016/j.carbpol.2021.118100. Epub 2021 Apr 24.
Moist, breathable and antibacterial microenvironment can promote cell proliferation and migration, which is beneficial to wound healing. Here, we fabricated a novel sodium alginate-chitosan oligosaccharide‑zinc oxide (SA-COS-ZnO) composite hydrogel by spontaneous Schiff base reaction, using aldehydated sodium alginate (SA), chitosan oligosaccharide (COS), and zinc oxide (ZnO) nanoparticles, which can provide a moist and antibacterial environment for wound healing. The porosity and swelling degree of SA-COS-ZnO hydrogel are 80% and 150%, respectively, and its water vapor permeability is 682 g/m/24h. The composite hydrogel showed good biocompatibility to blood cells, 3T3 cells, and 293T cells, and significant antibacterial activity against Escherichia coli, Staphylococcus aureus, Candida albicans, and Bacillus subtilis. Moreover, the hydrogel showed a promoting effect on wound healing in a rat scald model. The present study suggests that marine carbohydrates composite hydrogels are promising in wound care management.
湿润、透气且具有抗菌性的微环境可促进细胞增殖和迁移，这有利于伤口愈合。在此，我们通过自发席夫碱反应制备了一种新型海藻酸钠-壳寡糖-氧化锌（SA-COS-ZnO）复合水凝胶，使用了醛化海藻酸钠（SA）、壳寡糖（COS）和氧化锌（ZnO）纳米颗粒，其可为伤口愈合提供湿润且抗菌的环境。SA-COS-ZnO水凝胶的孔隙率和溶胀度分别为80%和150%，其水蒸气透过率为682 g/m/24h。该复合水凝胶对血细胞、3T3细胞和293T细胞表现出良好的生物相容性，对大肠杆菌、金黄色葡萄球菌、白色念珠菌和枯草芽孢杆菌具有显著的抗菌活性。此外，该水凝胶在大鼠烫伤模型中对伤口愈合表现出促进作用。本研究表明，海洋碳水化合物复合水凝胶在伤口护理管理方面具有广阔前景。
