School of Biomedical Engineering, Sun Yat-sen University, Shenzhen 518107, China.
Department of Hematology, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen 518107, China.
Carbohydr Polym. 2021 Aug 15;266:118097. doi: 10.1016/j.carbpol.2021.118097. Epub 2021 Apr 24.
Polysaccharides are well accepted biomaterials that have attracted considerable attention. Compared with other materials under research, polysaccharides show unique advantages: they are available in nature and are normally easily acquired, those acquired from nature show favorable immunogenicity, and are biodegradable and bioavailable. The bioactivity and possible applications are based on their chemical structure; however, naturally acquired polysaccharides sometimes have unwanted flaws that limit further applications. For this reason, carefully summarizing the possible modifications of polysaccharides to improve them is crucial. Structural modifications can not only provide polysaccharides with additional functional groups but also change their physicochemical properties. This review based on the structure-property relation summarizes the common chemical modifications of polysaccharides, the related bioactivity changes, possible functionalization methods, and major possible biomedical applications based on modified polysaccharides.
多糖是一种被广泛认可的生物材料，已经引起了相当多的关注。与其他正在研究的材料相比，多糖具有独特的优势：它们在自然界中大量存在且易于获取，从自然界中获取的多糖通常具有良好的免疫原性，并且可生物降解和生物利用。生物活性和可能的应用基于它们的化学结构；然而，天然获得的多糖有时具有不理想的缺陷，限制了它们的进一步应用。因此，仔细总结多糖的可能修饰以改善它们是至关重要的。结构修饰不仅可以为多糖提供额外的功能基团，还可以改变它们的物理化学性质。本篇综述基于结构-性质关系，总结了多糖的常见化学修饰、相关生物活性变化、可能的功能化方法以及基于修饰多糖的主要可能的生物医学应用。
