China Australia Joint Research Center for Infectious Diseases, School of Public Health, Xi'an Jiaotong University Health Science Centre, Xi'an, 710061, Shaanxi, People's Republic of China.
Melbourne Sexual Health Centre, Alfred Health, Melbourne, Australia.
Sci Rep. 2021 May 27;11(1):11087. doi: 10.1038/s41598-021-90627-3.
Mycoplasma genitalium (M. genitalium) is a recently recognised and important sexually transmitted infection among men who have sex with men (MSM). The role of oral sex, rimming, and kissing on M. genitalium transmission in MSM is unclear. We created four deterministic susceptible-infectious-susceptible epidemic models to examine the role that different sexual behaviours play in transmitting M. genitalium at the oropharynx, urethra anorectum among men who have sex with men in Australia. Our results suggest that oral and anal sex without other sexual practices (model 1) replicate well single site infection at the oropharynx, urethra and anorectum and also multi-site infection. If kissing or rimming are added to model 1 (i.e., model 2-4) no substantial improvements in the calibration of the models occur. Model 1 estimates that 3.4% of infections occur at the oropharynx, 34.8% at the urethra and 61.8% at the anorectum. Model 1 also estimates that the proportion of incident M. genitalium transmitted by anal sex was 82.4%, and by oral sex was about 17.6%. Our findings could provide an enhanced understanding of M. genitalium transmission in MSM, thus providing insights into what sexual practices contribute most to transmission.
生殖道支原体（M.genitalium）是最近被确认的一种重要的性传播感染，在男男性行为者（MSM）中较为常见。口交、肛交和接吻在 MSM 中传播 M.genitalium 的作用尚不清楚。我们创建了四个确定性易感-感染-易感传染病模型，以研究不同性行为在澳大利亚男男性行为者的口咽、尿道和肛门直肠部位传播 M.genitalium 中的作用。我们的研究结果表明，不伴有其他性行为的口交和肛交（模型 1）可以很好地复制单一部位感染（口咽、尿道和肛门直肠）和多部位感染。如果在模型 1 中加入亲吻或舔肛（即模型 2-4），则模型的校准不会有实质性的改善。模型 1 估计 3.4%的感染发生在口咽，34.8%发生在尿道，61.8%发生在肛门直肠。模型 1 还估计，肛门性交传播 M.genitalium 的比例为 82.4%，而口交约为 17.6%。我们的研究结果可以更深入地了解 MSM 中 M.genitalium 的传播，从而了解哪些性行为对传播的贡献最大。
