从脆弱齿孔菌发酵液中得到的新抗生素——齿孔菌素。

Dentipellin, a new antibiotic from culture broth of Dentipellis fragilis.

机构信息

Division of Biotechnology and Advanced Institute of Environmental and Bioscience, College of Environmental and Bioresource Sciences, Jeonbuk National University, Iksan-si, Republic of Korea.

出版信息

J Antibiot (Tokyo). 2021 Aug;74(8):538-541. doi: 10.1038/s41429-021-00426-1. Epub 2021 May 27.

DOI:10.1038/s41429-021-00426-1

PMID:34045694

Abstract

In our effort to find antimicrobial agents from higher fungi, we isolated a new compound, dentipellin (1), along with three known glycosylated diterpenes, erinacines A-C (2-4) from culture broth of Dentipellis fragilis. Their chemical structures were determined by spectroscopic methods including NMR and mass measurements. These compounds exhibited weak antibacterial and antifungal activities.

摘要

在我们从高等真菌中寻找抗菌剂的努力中，我们从齿菌属（Dentipellis fragilis）发酵液中分离得到了一个新化合物齿菌素（1），以及三个已知的糖基二萜化合物 erinacines A-C（2-4）。它们的化学结构通过包括 NMR 和质谱测量在内的光谱方法确定。这些化合物表现出微弱的抗菌和抗真菌活性。