Organic Research Labs, Department of Organic Chemistry, Andhra University, Visakhapatnam 530 003, India.
Bioorg Med Chem Lett. 2011 Dec 15;21(24):7522-5. doi: 10.1016/j.bmcl.2011.06.087. Epub 2011 Jun 29.
A new 8-hydroxy briarane diterpenoid (compound 1) with antifungal activity was isolated along with known compounds (2-5) from the gorgonian coral Junceellajuncea. On the basis of spectroscopic data (1D and 2D NMR, MS), the structure of the compound 1 was established as (1S,2S,8S,9S,10S,11R,12R,14S,17R)-11,20-epoxy-14-(3-methylbutanoyl)-2,9,12-triacetoxy-8-hydroxybriar-5(16)-en-18,7-olide. Compound 1 exhibited significant activity against fungi (Aspergillus niger, Candida albicans and Penicillium notatum) but the other compounds (2-5) did not exhibit the activity against fungi.
从柳珊瑚 Junceella juncea 中分离得到具有抗真菌活性的新的 8-羟基海鞘二萜类化合物（化合物 1）以及已知化合物（2-5）。根据光谱数据（1D 和 2D NMR，MS），确定了化合物 1 的结构为（1S,2S,8S,9S,10S,11R,12R,14S,17R）-11,20-环氧-14-（3-甲基丁酰基）-2,9,12-三乙酰氧基-8-羟基海鞘-5(16)-烯-18,7-内酯。化合物 1 对真菌（黑曲霉、白色念珠菌和青霉菌）表现出显著的活性，而其他化合物（2-5）则没有抗真菌活性。
