一株柳珊瑚中分离得到的新型抗真菌海兔烷二萜。

A new antifungal briarane diterpenoid from the gorgonian Junceella juncea Pallas.

机构信息

Organic Research Labs, Department of Organic Chemistry, Andhra University, Visakhapatnam 530 003, India.

出版信息

Bioorg Med Chem Lett. 2011 Dec 15;21(24):7522-5. doi: 10.1016/j.bmcl.2011.06.087. Epub 2011 Jun 29.

DOI:10.1016/j.bmcl.2011.06.087

PMID:22071302

Abstract

A new 8-hydroxy briarane diterpenoid (compound 1) with antifungal activity was isolated along with known compounds (2-5) from the gorgonian coral Junceellajuncea. On the basis of spectroscopic data (1D and 2D NMR, MS), the structure of the compound 1 was established as (1S,2S,8S,9S,10S,11R,12R,14S,17R)-11,20-epoxy-14-(3-methylbutanoyl)-2,9,12-triacetoxy-8-hydroxybriar-5(16)-en-18,7-olide. Compound 1 exhibited significant activity against fungi (Aspergillus niger, Candida albicans and Penicillium notatum) but the other compounds (2-5) did not exhibit the activity against fungi.

摘要

从柳珊瑚 Junceella juncea 中分离得到具有抗真菌活性的新的 8-羟基海鞘二萜类化合物（化合物 1）以及已知化合物（2-5）。根据光谱数据（1D 和 2D NMR，MS），确定了化合物 1 的结构为（1S,2S,8S,9S,10S,11R,12R,14S,17R）-11,20-环氧-14-（3-甲基丁酰基）-2,9,12-三乙酰氧基-8-羟基海鞘-5(16)-烯-18,7-内酯。化合物 1 对真菌（黑曲霉、白色念珠菌和青霉菌）表现出显著的活性，而其他化合物（2-5）则没有抗真菌活性。