Dermatology and Venereology Department, Mohammed V University, Rabat, Morocco.
Pan Afr Med J. 2021 Mar 4;38:236. doi: 10.11604/pamj.2021.38.236.27303. eCollection 2021.
Toxic epidermal necrolysis-like acute cutaneous lupus erythematosus (TEN-like ACLE) is a rare manifestation of systemic lupus erythematosus (SLE). Because of its rarity, little is known about this entity. In this report, we describe a case of two women previously diagnosed with SLE that presented TEN-like skin lesions. The common elements in both patients were the initial disposition of the lesions on the photoexposed areas, the positivity of Nikolsky´s sign, the discrete mucosal attrition compared to that observed during TEN, and the simultaneous appearance of dermatological lesions with an extra-cutaneous flare of lupus disease. The skin biopsy in both cases showed epidermal necrosis with an identification of lupus band on direct immunofluorescence. Systemic corticosteroids were used with a good evolution after 2 weeks. Skin damage is an indicator of disease activity, and careful search for extracutaneous involvement is obligatory to prevent further complications.
中毒性表皮坏死松解症样急性皮肤狼疮（TEN 样 ACLE）是系统性红斑狼疮（SLE）的一种罕见表现。由于其罕见性，对该疾病知之甚少。在本报告中，我们描述了两例先前诊断为 SLE 的女性出现 TEN 样皮肤损伤的病例。两名患者的共同特征是皮损最初出现在光暴露部位，尼氏征阳性，与 TEN 相比黏膜磨损不明显，以及皮肤病变与狼疮疾病的皮肤外发作同时出现。两例皮肤活检均显示表皮坏死，直接免疫荧光显示狼疮带。均使用全身皮质类固醇治疗，2 周后病情好转。皮肤损伤是疾病活动的指标，必须仔细寻找皮肤外受累情况，以防止进一步并发症。
