Aiempanakit K, Chiratikarnwong K, Juthong S, Auepemkiate S
1 Division of Dermatology, Department of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand.
2 Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand.
Lupus. 2018 Oct;27(11):1860-1863. doi: 10.1177/0961203318789766. Epub 2018 Jul 20.
A 60-year-old female was diagnosed with progressive systemic sclerosis and interstitial lung disease of two months' duration. The patient was treated for Raynaud phenomenon with aspirin, nifedipine, colchicine, and naproxen. Two weeks after treatment, she developed widespread erythematous patches with blistering eruptions on the face, torso, and extremities, and also had erosion on the oral mucosa. Skin biopsy for histopathology and direct immunofluorescent studies were suggestive of lupus erythematosus. To the best of our knowledge, this is the first case of toxic epidermal necrolysis-like acute cutaneous lupus erythematosus in a patient with progressive systemic sclerosis.
一名60岁女性被诊断为进行性系统性硬化症和病程两个月的间质性肺病。该患者曾用阿司匹林、硝苯地平、秋水仙碱和萘普生治疗雷诺现象。治疗两周后，她的面部、躯干和四肢出现广泛的红斑性斑块伴水疱性皮疹，口腔黏膜也有糜烂。皮肤组织病理学活检和直接免疫荧光研究提示为红斑狼疮。据我们所知，这是首例进行性系统性硬化症患者发生中毒性表皮坏死松解型急性皮肤红斑狼疮的病例。
