Mamballikalam Gopinath, Senthilkumar S, Clinto C O, Ahamed Basith P M, Jaon Bos R C, Thomas Tems
R&D, Bharathiar University, Coimbatore, Tamilnadu, India.
Department of Radiation Oncology, Aster Medcity, Kochi, Kerala, India.
Rep Pract Oncol Radiother. 2021 Feb 25;26(1):111-118. doi: 10.5603/RPOR.a2021.0018. eCollection 2021.
The aim was to study the impact of the flattening filter free (FFF) beam on overall treatment time for frameless intracranial radiosurgery using TrueBeam LINAC.The development of frameless stereotactic radiosurgery (SRS) is possible due to the incorporation of image guidance in the delivery of treatment. It is important to analyze the cost and benefits of FFF beams for treating SRS by understanding the impact of FFF beams in reducing the treatment time.
Dynamic conformal arc (DCA ) and volumetric arc therapy (VMAT) plans were generated using 6 MV with a flattening filter (FF) and FFF beams. Overall treatment time was divided into beam on time (BOT) and beam off time (BFT). Percentage beam on time reduction (PBOTR) and Percentage total time reduction (PTTR) factors were defined for the comparison.
BOT reduction was observed to be significant for higher dose per fraction but subjected to the treatment technique and modulation differences. PBOTR values are much higher than PTTR values. The 39.9% of PBOTR resulted in only 8% PTTR for DCA and 65.3% resulted in 15.9% PTTR for VMAT.
Major BFT was utilized for imaging and verification. FFF beam significantly reduced the beam on time and was found to be most effective if the fractional dose was as high as that for SRS. Newly defined PBOTR and PTTR factors are very useful indicators to evaluate the efficacy of FFF beams in terms of time reduction.
本研究旨在探讨使用TrueBeam直线加速器的无 flattening 滤过器(FFF)射束对无框架颅内放射外科治疗总治疗时间的影响。由于在治疗过程中引入了图像引导技术,无框架立体定向放射外科(SRS)得以发展。通过了解FFF射束对缩短治疗时间的影响,分析其用于治疗SRS的成本效益非常重要。
使用带有 flattening 滤过器(FF)的6MV射束和FFF射束生成动态适形弧(DCA)和容积弧形调强放疗(VMAT)计划。总治疗时间分为射束开启时间(BOT)和射束关闭时间(BFT)。定义了射束开启时间减少百分比(PBOTR)和总时间减少百分比(PTTR)因子用于比较。
观察到每次分割剂量较高时BOT减少显著,但受治疗技术和调制差异影响。PBOTR值远高于PTTR值。对于DCA,39.9%的PBOTR仅导致8%的PTTR,对于VMAT,65.3%的PBOTR导致15.9%的PTTR。
主要的BFT用于成像和验证。FFF射束显著缩短了射束开启时间,并且发现如果分割剂量与SRS一样高,其最为有效。新定义的PBOTR和PTTR因子是评估FFF射束在减少时间方面疗效的非常有用的指标。