Setiabudiawan Budi, Sitaresmi Mei Neni, Sapartini Gartika, Citraresmi Endah, Sekartini Rini, Putra Azwin Mengindra, Jo Juandy
Department of Child Health, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia.
Department of Child Health, Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia.
Pediatr Gastroenterol Hepatol Nutr. 2021 May;24(3):316-324. doi: 10.5223/pghn.2021.24.3.316. Epub 2021 May 4.
The use of soy-based infant formula has increased widely in infants with cow's milk allergy (CMA). This study aimed to provide evidence on the growth pattern of CMA infants fed with soy-based infant formula in an Indonesian setting.
A multi-site, intervention study was conducted among full-term and normal birth weight CMA infants. Within six months, the subjects were provided with a soy-based infant formula. Weight, height, and head circumference were measured at baseline, weeks 4, 8, 12, 16, 20, and 24. Adverse events were recorded by scoring atopic dermatitis and symptom-based clinical scores.
Based on the World Health Organization growth chart, we found that most of subjects had normal nutritional status for weight-for-age, length-for-age, weight-for-length, and head-circumference-for-age. There were statistically significant differences between baseline and end-line for weight-for-age, length-for-age, weight-for-length, and head circumference-for-age nutritional status. No allergic symptoms or intolerance toward soy formula were observed at the end of the intervention period.
These results show that infants fed with soy-based infant formula have a normal pattern of growth.
大豆基婴儿配方奶粉在牛奶蛋白过敏（CMA）婴儿中的使用已广泛增加。本研究旨在提供关于印度尼西亚环境中喂养大豆基婴儿配方奶粉的CMA婴儿生长模式的证据。
对足月和正常出生体重的CMA婴儿进行了一项多地点干预研究。在六个月内，为受试者提供大豆基婴儿配方奶粉。在基线、第4、8、12、16、20和24周测量体重、身高和头围。通过对特应性皮炎进行评分和基于症状的临床评分来记录不良事件。
根据世界卫生组织生长图表，我们发现大多数受试者在年龄别体重、年龄别身长、身长别体重和年龄别头围方面营养状况正常。年龄别体重、年龄别身长、身长别体重和年龄别头围营养状况在基线和末期之间存在统计学显著差异。在干预期结束时，未观察到对大豆配方奶粉的过敏症状或不耐受情况。
这些结果表明，喂养大豆基婴儿配方奶粉的婴儿生长模式正常。
