Sasaki F, Takada N, Hata Y, Kyunoh K, Uchino J
First Department of Surgery, School of Medicine, Hokkaido University.
Jpn J Antibiot. 1988 Apr;41(4):460-6.
Cefbuperazone (CBPZ) at a dose of 2 g was administered postoperatively by intravenous drip infusion to 9 patients subjected to radical mastectomy and 10 others subjected to thyroidectomy then levels of CBPZ in postoperative exudates were measured and its prophylactic effect on postoperative infections was determined. 1. Serum CBPZ levels in the patients after cancer mastectomy and thyroidectomy on postoperative day 1 were similar to those in healthy adults. 2. Levels of CBPZ in the postoperative exudates in patients subjected to cancer mastectomy reached a mean peak value of 66.3 micrograms/ml (range: 26.0-99.6 micrograms/ml) in 0-3 hours after administration, and the mean CBPZ level at 6 hours after administration was 33.3 micrograms/ml (range: 19.1-54.1 micrograms/ml). 3. As compared to the cases of cancer mastectomy, levels of CBPZ in postoperative exudates in patients subjected to thyroidectomy varied considerably from a patient to another: a mean peak level of 76.4 micrograms/ml (range: 31.3-128 micrograms/ml) appeared in 0 to 6 hours after administration. 4. There was no correlation between CBPZ levels in the exudate and hemoglobin levels or hematocrit values. 5. Likely because of the CBPZ administration at 4 g/day for 2 to 6 days postoperatively to 19 patients, postoperative infection was absent and no side effect attributable to this drug occurred in any of the patients. Because levels of CBPZ in postoperative exudates in patients subjected to cancer mastectomy or thyroidectomy were greater than MICs for principal Gram-positive and Gram-negative bacteria, it is likely that this drug is a useful agent for prophylaxis against postoperative infections in patients undergoing cancer mastectomy or thyroidectomy.
对9例行根治性乳房切除术的患者和10例行甲状腺切除术的患者术后静脉滴注2g头孢哌酮（CBPZ），然后测定术后渗出液中CBPZ的水平，并确定其对术后感染的预防作用。1. 乳房癌根治术和甲状腺切除术后第1天患者血清CBPZ水平与健康成年人相似。2. 乳房癌根治术患者术后渗出液中CBPZ水平在给药后0 - 3小时达到平均峰值66.3微克/毫升（范围：26.0 - 99.6微克/毫升），给药后6小时的平均CBPZ水平为33.3微克/毫升（范围：19.1 - 54.1微克/毫升）。3. 与乳房癌根治术患者相比，甲状腺切除术患者术后渗出液中CBPZ水平个体差异较大：给药后0至6小时出现的平均峰值水平为76.4微克/毫升（范围：31.3 - 128微克/毫升）。4. 渗出液中CBPZ水平与血红蛋白水平或血细胞比容值之间无相关性。5. 可能由于对19例患者术后2至6天每天给予4g CBPZ，术后未发生感染，且所有患者均未出现该药物的副作用。由于乳房癌根治术或甲状腺切除术患者术后渗出液中CBPZ水平高于主要革兰氏阳性和革兰氏阴性菌的最低抑菌浓度，该药物可能是预防乳房癌根治术或甲状腺切除术患者术后感染的有效药物。
