Seiga K, Sugiyama Y
Jpn J Antibiot. 1984 Dec;37(12):2519-30.
Cefbuperazone (CBPZ), a new cephamycin antibiotic, was studied for the distribution in the genital organs and the excretion to the pelvic dead space exudate by bioassay, and the following results were obtained. CBPZ was rapidly distributed into the various tissues by intravenous drip infusion of 0.5 g and 1.0 g for 1 hour. Those levels depended on serum levels and the ratios (tissue level/serum level) were about 15-25%. Obvious dose response between 0.5 g and 1.0 g of CBPZ was recognized for serum levels as well as tissue levels. Serum and tissue levels were respectively analyzed by two- and three-compartment open model. Consequently, the obtained simulation curve approximated to the observed results. The simulation curve and pharmacokinetic parameters by one-compartment open model were appropriate for CBPZ levels in the pelvic dead space exudate.
头孢布宗（CBPZ）是一种新型头孢霉素类抗生素，通过生物测定法研究了其在生殖器官中的分布以及向盆腔死腔渗出液中的排泄情况，结果如下。通过静脉滴注0.5 g和1.0 g 1小时，CBPZ迅速分布到各种组织中。这些水平取决于血清水平，其比值（组织水平/血清水平）约为15 - 25%。在0.5 g至1.0 g的CBPZ之间，血清水平和组织水平均呈现明显的剂量反应。血清和组织水平分别采用二室和三室开放模型进行分析。因此，得到的模拟曲线与观察结果相近。单室开放模型的模拟曲线和药代动力学参数适用于盆腔死腔渗出液中的CBPZ水平。
