Ma Mengsi, Zhong Yalan, Jiang Xulin
Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University, 299 Bayi Road, Wuhan 430072, P. R. China.
J Mater Chem B. 2021 Jun 2;9(22):4567-4576. doi: 10.1039/d1tb00724f.
Prevention of bacterial infection, acceleration of wound closure and promotion of skin regeneration are crucial in the wound healing process. In this work, the photothermal activity of an injectable thermosensitive composite hydrogel based on hydroxypropyl chitin (HPCH), tannic acid (TA) and ferric ions (Fe3+) was studied. It was found that the photothermal efficiency was enhanced when the molar ratio of Fe3+/TA increased up to 20. The composite hydrogel possessed good cytocompatibility and hemocompatibility with a low dosage of the antibacterial agent TA. In vitro and in vivo antibacterial tests showed that the HPCH/TA/Fe hydrogel possessed an effective and rapid bactericidal effect with 10 minutes of near-infrared laser irradiation. Furthermore, the combination of a low-level laser therapy with the hydrogel is conducive to the acceleration of wound closure and promotion of skin tissue repair. Thus, the injectable photothermally active antibacterial composite hydrogel has great potential for the infected skin wound regeneration in clinical applications.
预防细菌感染、加速伤口愈合和促进皮肤再生在伤口愈合过程中至关重要。在这项工作中，研究了一种基于羟丙基壳聚糖（HPCH）、单宁酸（TA）和铁离子（Fe3+）的可注射热敏复合水凝胶的光热活性。发现当Fe3+/TA的摩尔比增加到20时，光热效率提高。该复合水凝胶在低剂量抗菌剂TA的情况下具有良好的细胞相容性和血液相容性。体外和体内抗菌试验表明，HPCH/TA/Fe水凝胶在近红外激光照射10分钟时具有有效且快速的杀菌效果。此外，低强度激光疗法与水凝胶的联合使用有利于加速伤口愈合和促进皮肤组织修复。因此，这种可注射的具有光热活性的抗菌复合水凝胶在临床应用中对于感染性皮肤伤口再生具有巨大潜力。
