Department of Biological Sciences, University of Alberta, Edmonton, Alberta, Canada.
Women & Children's Health Research Institute, University of Alberta, Edmonton, Alberta, Canada.
J Anat. 2021 Oct;239(4):801-828. doi: 10.1111/joa.13459. Epub 2021 May 28.
The vertebrate inner ear is a labyrinthine sensory organ responsible for perceiving sound and body motion. While a great deal of research has been invested in understanding the auditory system, a growing body of work has begun to delineate the complex developmental program behind the apparatuses of the inner ear involved with vestibular function. These animal studies have helped identify genes involved in inner ear development and model syndromes known to include vestibular dysfunction, paving the way for generating treatments for people suffering from these disorders. This review will provide an overview of known inner ear anatomy and function and summarize the exciting discoveries behind inner ear development and the evolution of its vestibular apparatuses.
脊椎动物内耳是一个错综复杂的感觉器官,负责感知声音和身体运动。虽然人们投入了大量的研究来了解听觉系统,但越来越多的工作开始描绘参与前庭功能的内耳器官背后复杂的发育程序。这些动物研究有助于确定与内耳发育相关的基因,并为已知包括前庭功能障碍在内的综合征建立模型,为治疗这些疾病的患者铺平了道路。这篇综述将提供内耳解剖结构和功能的概述,并总结内耳发育和其前庭器官进化背后令人兴奋的发现。