State Key Laboratory of Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha, 410082, People's Republic of China.
Mikrochim Acta. 2021 May 28;188(6):210. doi: 10.1007/s00604-021-04849-3.
A self-healing smart PhC hydrogel sensor that combines the optical property of photonic crystal and the dynamic regeneration property of boronate ester bond has been prepared for determination of glucose and related saccharides using Debye diffraction ring detection. The boronate ester bond formed through phenylboronic acid and dopamine endows the hydrogel network self-healing ability, and the tensile stress of the healing hydrogel can recover to 94.4%; this excellent self-healing property can effectively improve the reliability and lifetime of the hydrogel. Due to the high bonding capacity between 1,2- and 1,3-diol and phenylboronic acid, the hydrogel sensor has a good recognition ability for glucose and related saccharides. The reaction between the monosaccharides and the phenylboronic acid group makes the sensor swell and the diameter of the Debye diffraction ring decrease. The sensor shows good reuse and responsive ability for saccharides; the RSD of the recoverability assays is 4.3%. The determination range of the sensor to glucose is 0.5 to 12 mM. The sensor also has good response to glucose in urine, exhibiting potential application value in the preliminary screening of diabetes. Although the sensor has poor selectivity for specific monosaccharides, the process of measuring the Debye ring makes the determination no longer rely on expensive and complicated equipment and greatly simplifies the determining process and reduces the cost of determination, which shows a broad application prospect. The boronate ester bond formed through phenylboronic acid and dopamine results in the self-healing property of hydrogel network, which can effectively improve the reliability and lifetime of hydrogel. And due to the high bonding capacity between 1,2- and 1,3-diol and phenylboronic acid, the smart hydrogel sensor has a good recognition ability for glucose and related saccharides. The reaction between the monosaccharides and the phenylboronic acid group breaks the original boronate ester bond; this will lead to a decrease in cross-linking density of the PhC hydrogel sensor and further makes the sensor swell and the diameter of the Debye diffraction ring decrease.
一种自修复智能光子晶体水凝胶传感器，结合了光子晶体的光学性质和硼酸酯键的动态再生性质，已被制备用于使用德拜衍射环检测来测定葡萄糖和相关糖。通过苯硼酸和多巴胺形成的硼酸酯键赋予水凝胶网络自修复能力，修复水凝胶的拉伸应力可恢复到 94.4%；这种优异的自修复性能可以有效提高水凝胶的可靠性和寿命。由于 1,2-和 1,3-二醇与苯硼酸之间的高结合能力，水凝胶传感器对葡萄糖和相关糖具有良好的识别能力。单糖与苯硼酸基团的反应使传感器膨胀，德拜衍射环的直径减小。传感器对糖具有良好的重复使用和响应能力；回收率测定的 RSD 为 4.3%。传感器对葡萄糖的测定范围为 0.5 至 12mM。传感器对尿液中的葡萄糖也有良好的响应，在糖尿病的初步筛查中具有潜在的应用价值。尽管传感器对特定单糖的选择性较差，但测量德拜环的过程使得测定不再依赖于昂贵且复杂的设备，大大简化了测定过程并降低了测定成本，具有广阔的应用前景。通过苯硼酸和多巴胺形成的硼酸酯键导致水凝胶网络具有自修复性能，这可以有效提高水凝胶的可靠性和寿命。并且由于 1,2-和 1,3-二醇与苯硼酸之间的高结合能力，智能水凝胶传感器对葡萄糖和相关糖具有良好的识别能力。单糖与苯硼酸基团的反应破坏了原有的硼酸酯键；这将导致 PhC 水凝胶传感器的交联密度降低，进一步使传感器膨胀，德拜衍射环的直径减小。
