Department of General Surgery, Jinling Hospital , Medical School of Nanjing University , Nanjing 210002 , China.
State Key Laboratory of Bioelectronics, School of Biological Science and Medical Engineering , Southeast University , Nanjing 210096 , China.
ACS Nano. 2018 Oct 23;12(10):10493-10500. doi: 10.1021/acsnano.8b06237. Epub 2018 Sep 28.
Wound healing is one of the most important and basic issues faced by the medical community. In this paper, we present biomass-composited inverse opal particles with a series of advanced features for drug delivery and wound healing. The particles were derived by using chitosan biomass to negatively replicate spherical colloid crystal templates. Because of the interconnected porous structures, various forms of active drugs, including fibroblast growth factor could be loaded into the void spaces of the inverse opal particles and encapsulated by temperature-responsive hydrogel. This endowed the composited particles with the capability of intelligent drug release through the relatively high temperature caused by the inflammation reaction at wound sites. Because the structural colors and characteristic reflection peaks of the composited inverse opal particles are blue-shifted during the release process, the drug delivery can be monitored in real time. It was demonstrated that the biomass-composited microcarriers were able to promote angiogenesis, collagen deposition, and granulation-tissue formation as well as reduce inflammation and thus significantly contributed to wound healing. These features point to the potential value of multifunctional biomass inverse opal particles in biomedicine.
伤口愈合是医学界面临的最重要和最基本的问题之一。在本文中，我们提出了具有一系列先进功能的生物量复合的反蛋白石颗粒，用于药物输送和伤口愈合。这些颗粒是通过使用壳聚糖生物质来负复制球形胶体晶体模板而得到的。由于具有互连的多孔结构，各种形式的活性药物，包括成纤维细胞生长因子，可以被装载到反蛋白石颗粒的空隙中，并被温度响应性水凝胶包裹。这使复合颗粒具有通过伤口部位炎症反应引起的相对较高温度进行智能药物释放的能力。由于在释放过程中复合反蛋白石颗粒的结构颜色和特征反射峰发生蓝移，因此可以实时监测药物输送。结果表明，生物质复合微载体能够促进血管生成、胶原蛋白沉积和肉芽组织形成，减少炎症，从而显著促进伤口愈合。这些特性表明多功能生物质反蛋白石颗粒在生物医学中的潜在价值。
