Department of Pathology and Laboratory Medicine, Boston School of Medicine, Boston, MA, USA.
Methods Mol Biol. 2021;2321:177-189. doi: 10.1007/978-1-0716-1488-4_16.
Biomarkers have been used in sepsis to assist with the diagnosis of disease as well as determining the severity of disease, that is, prognosis. These biomarkers are based on the presence of discrete molecules within the blood. Unfortunately, in 2020, a single biomarker does not have sufficient sensitivity and specificity to definitively rule in or rule out sepsis. Biomarkers have shown better performance in animal models of disease.
生物标志物已被用于脓毒症，以辅助疾病诊断以及确定疾病的严重程度，即预后。这些生物标志物基于血液中离散分子的存在。不幸的是，在 2020 年，单一的生物标志物的灵敏度和特异性不足以明确诊断或排除脓毒症。生物标志物在疾病的动物模型中表现出更好的性能。
