Zhang Kuikui, Zhang Jiaxue, Wang Fenfang, Kong Desheng
College of Engineering and Applied Sciences, State Key Laboratory of Analytical Chemistry for Life Science, and Jiangsu Key Laboratory of Artificial Functional Materials, Nanjing University, Nanjing 210093, China.
ACS Sens. 2021 Jun 25;6(6):2261-2269. doi: 10.1021/acssensors.1c00316. Epub 2021 May 28.
Stretchable and wearable sensors allow intimate integration with the human body for health and fitness monitoring. In addition to the acquisition of various physical parameters, quantitative analysis of chemical biomarkers present in sweat may provide vital insights into the physiological state of an individual. A widely investigated system utilizes electrochemical techniques for continuous monitoring of these biomarkers. The required supporting electronics and batteries are often challenging to form a deformable system. In this study, an intrinsically stretchable sensing patch is developed with compliant mechanical properties for conformal attachment to the skin and reliable collection of sweat. In these patches, superhydrophilic colorimetric assays consisting of thermoplastic polyurethane nanofiber textiles decorated with silica nanoparticles are assembled over a styrene-ethylene-butylene-styrene-based superhydrophobic substrate, thereby generating a large wettability contrast to efficiently concentrate the sweat. The system supports multiplexed colorimetric analysis of sweat to quantify pH and ion concentrations with images acquired using smartphones, in which the influence of ambient lighting conditions is largely compensated with a set of reference color markers. Successful demonstrations of analysis of sweat after physical exercises effectively illustrate the practical suitability of the sensing patch, which is attractive for advanced health monitoring, clinical diagnostics, and competitive sports.
可拉伸可穿戴传感器能够与人体紧密集成，用于健康和健身监测。除了获取各种物理参数外，对汗液中存在的化学生物标志物进行定量分析，可能会为个人的生理状态提供重要见解。一种被广泛研究的系统利用电化学技术来持续监测这些生物标志物。所需的支持电子设备和电池通常难以形成可变形系统。在本研究中，开发了一种具有顺应性机械性能的本征可拉伸传感贴片，用于与皮肤贴合以及可靠地收集汗液。在这些贴片中，由装饰有二氧化硅纳米颗粒的热塑性聚氨酯纳米纤维织物组成的超亲水比色测定法被组装在基于苯乙烯 - 乙烯 - 丁烯 - 苯乙烯的超疏水基底上，从而产生大的润湿性对比度以有效浓缩汗液。该系统支持对汗液进行多重比色分析，以通过使用智能手机获取的图像来量化pH值和离子浓度，其中通过一组参考颜色标记在很大程度上补偿了环境光照条件的影响。对体育锻炼后汗液分析的成功演示有效地说明了传感贴片的实际适用性，这对于先进的健康监测、临床诊断和竞技体育具有吸引力。
